NCT07486297尚未招募不适用
A Multicenter Randomized Controlled Trial Evaluating the Effect of Acupuncture on the Success Rate in Patients With Recurrent Implantation Failure
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 208
- 试验地点
- 1
- 主要终点
- clinical pregnancy
研究概览
简要总结
To conduct a multi-center, randomized, controlled clinical study aimed at formally evaluating the impact of pressing therapy on the success rate in patients with recurrent implantation failure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Meets the criteria for RIF diagnosis (≥ 2 instances of unsuccessful transfer of high-quality embryos).
- •Age: 20 to 40 years old.
- •Planning for a cycle involving the transfer of frozen-thawed embryos (FET).
- •Possession of a transplantable D3 frozen embryo (≥6 cells) or a frozen blastocyst (≥3BC).
- •Estradiol-progesterone replacement therapy: endometrial thickness ≥ 7 mm within the period of endometrial transformation.
排除标准
- •Individuals planning to undergo preimplantation genetic diagnosis (PGD).
- •Recipients of egg donations.
- •Chromosomal abnormalities in either spouse or one partner (excluding chromosomal polymorphisms).
- •Patients with known embryo-related factors leading to implantation failure.
- •Abnormalities of the uterus that may affect implantation (including uterine malformations, uterine tuberculosis, submucosal myomas, severe uterine adhesions, severe uterine endometriosis, myomas with a diameter of ≥4 cm, and so on).
- •Recurrent spontaneous abortions (loss of a fetus before 28 weeks of gestation occurring twice or more).
- •Individuals with other endocrine disorders, such as thyroid disorders, hyperprolactinemia, insulin resistance, diabetes, and adrenal disorders, whose hormone levels have not been well-controlled over the past 3 months.
- •Individuals with untreated hydrosalpinx;
- •Individuals with a Body Mass Index (BMI) below 18 and above 25 kg/m
- •Men with severe abnormalities in semen quality. Individuals with a history of needle phobia.
研究组 & 干预措施
Placebo group
Placebo Comparator
nonpenetrating placebo needles
干预措施: Placebo Group (Device)
acupuncture group
Experimental
indwelling intradermal needles
干预措施: Acupuncture group (Device)
结局指标
主要结局
clinical pregnancy
时间窗: 1 year
defined as ultrasonographic detection of an intrauterine gestational sac following embryo transfer
次要结局
- β-hCG-positive pregnancy(1 year)
- Endometrial thickness(1 year)
- endometrial blood flow(1 year)
- anxiety assessment(1 year)
- depression assessment(1 year)
- sleep quality assessment(1 year)
研究者
Cui Hong Zheng
Principal Investigator, Clinical Professor
Huazhong University of Science and Technology
研究点 (1)
Loading locations...
相似试验
尚未招募
4 期
Effects of Recombinant Human Growth Hormone in Elderly Patients With Moderate to Severe Acute Brain Injury (GH-ABI-RCT)NCT07481656Anhui Provincial Hospital160
尚未招募
不适用
The Coronary Sinus Balloon Pump in STEMINCT07354035Shanghai MicroPort Rhythm MedTech Co., Ltd.177
招募中
不适用
Clinical Investigation Between the Topical Administration of a Tear Substitute With Ancillary Medicinal Substance and Hyaluronic Acid 0.3% (FBV_01) vs Hyaluronic Acid 0.3% in Subjects in the Treatment From Moderate to Severe DEDNCT07412860FB Vision S.p.A74
尚未招募
不适用
Partially Hydrolyzed Whey Protein Formula for Infants With Mild AllergyNCT07449507Ruijin Hospital160
已完成
4 期
This clinical trial is to study the digital method for eye lens to be placed during cataract surgery by comparing with the manual methodCTRI/2024/04/065250Center for Application Research in India (CARIn) Carl Zeiss India80