investigating the effect of probiotic supplements on blood pressure changes in patients undergoing hemodialysis at Namazi Hospital in Shiraz. Randomized clinical trial
Not Applicable
Recruiting
- Conditions
- Dependence on renal dialysisHemodialysis patients.Z99.2
- Registration Number
- IRCT20230701058626N1
- Lead Sponsor
- Shiraz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 152
Inclusion Criteria
Patients with chronic kidney disease who undergo hemodialysis for more than three months are included in the study
Exclusion Criteria
Active cancer
Active infection
Pregnancy
Sensitivity to probiotic compounds
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Arterial blood pressure. Timepoint: before and after treatment. Method of measurement: Arterial blood pressure of patients undergoing dialysis is taken and recorded in three stages before, during and after dialysis.
- Secondary Outcome Measures
Name Time Method 1. Determining the average arterial blood pressure before, during, and after receiving probiotics and placebo in experimental groups. Timepoint: before, during, and after receiving probiotics and placebo. Method of measurement: Digital pressure gauge.;Determining the average angiotensin-converting enzyme (ACE) activity before and after receiving probiotics and placebo in experimental groups. Timepoint: before and after receiving probiotics and placebo. Method of measurement: Spectrophotometry.;Determining the average total antioxidative capacity (TAC), and total oxidative state (TOS) measure before and after receiving probiotics and placebo in experimental groups. Timepoint: before and after receiving probiotics and placebo. Method of measurement: Spectrophotometry.;Determining the average complete blood count (CBC) before and after receiving probiotics and placebo in experimental groups. Timepoint: before and after receiving probiotics and placebo. Method of measurement: Autolyzer.