Intermittent Hypoxia and Upper Limb Training in Individuals With Spinal Cord Injury
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 2
- 主要终点
- Maximal Elbow Strength [Newtons]
研究概览
简要总结
In this current study, the examiners examine some of the mechanisms of how Acute Intermittent Hypoxia (AIH) effects the upper extremity of survivors of spinal cord injury. This is accomplished both with the use of a load cell to determine elbow strength changes and high density grid electromyography (EMG) to record bicep muscle activations before and after bouts of AIH
详细描述
It has been shown previously that there is an increase in strength in survivors of spinal cord injury after brief bouts of Acute Intermittent Hypoxia. In this study, participants are fitted with a high density EMG electrode on the biceps brachii, and attached to a load cell at the wrist, they are asked to flex and extend their elbow at various levels of intensity. This is performed before and after the 30 minute session of AIH. The investigators hope to identify specific types of motor units of the upper extremity of survivors of spinal cord injury after AIH to help further our understanding of what mechanisms may be causing the known increase in muscle strength post AIH
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •History of Spinal Cord Injury from C3-T4
- •Non-progressive spinal cord injury
- •More than 6 months since initial Spinal Cord injury
- •Ability to understand and willingness to sign written informed consent
排除标准
- •Presence of any of the following medical conditions: Congestive heart failure, arrhythmia, uncontrolled high blood pressure, uncontrolled diabetes mellitus, COPD/emphysema and severe asthma
- •Persons with known coronary artery disease, a history of myocardial infarction, or known carotid or intracerebral artery stenosis
- •Medical clearance will be required if participant is taking any other investigational agents
- •Women who are pregnant or nursing
- •Individuals with tracheostomy
- •Cannot pursue other research studies which may interfere
- •Unable to consent
- •Individuals who are not yet adults (infants, children, teenagers)
- •Prisoners
结局指标
主要结局
Maximal Elbow Strength [Newtons]
时间窗: 30 minutes Post intervention
Recordings of the elbow joint torque are taken while the participant is asked to flex and extend the elbow voluntarily at a maximum level of intensity
次要结局
- Biceps Brachii Muscle activation [μv](30 minutes post intervention)
研究者
Milap Sandhu
Principal Investigator
Shirley Ryan AbilityLab