Determination of CYP3A activity in patients using plasma amlodipine exposure and metabolism
Not Applicable
Recruiting
- Conditions
- hypertension
- Registration Number
- JPRN-UMIN000033745
- Lead Sponsor
- Hamamatsu University School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
Not provided
Exclusion Criteria
Patients from whom written informed consent was not obtained
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Assessment of CYP3A activity by determining amlodipine and its two metabolites (dehydroamlodipine and O-des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine) in Human Plasma
- Secondary Outcome Measures
Name Time Method Assessment of CYP3A activity by determining plasma 4beta-hydroxycholesterol as an endogenous CYP3A metric