Sleep, Breathing and Psychomotor Performance at Altitude: A Physiologic Study in Healthy Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 51
- 试验地点
- 2
- 主要终点
- apnea/hypopnea index
研究概览
简要总结
This study investigates the effect of altitude exposure on sleep, breathing and psychomotor performance in healthy subjects.
详细描述
Sleep is essential for well being and performance. Sleep disturbances by recurrent apnea and hypoxia in patients with obstructive sleep apnea syndrome impair quality of life, cognitive and cardiovascular functions. Similar consequences occur in healthy subjects exposed to hypoxia at altitude due to periodic breathing with recurrent central apnea. This project will investigate effects of altitude on sleep, breathing, psychomotor performance and on the cardiovascular system in healthy subjects and patients with sleep apnea. The results will help to better understand mechanisms of sleep disturbances and psychomotor impairment induced by hypoxia and to prevent adverse effects of altitude exposure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy men
- •residence at <800m
排除标准
- •any active disease requiring treatment
- •requirement for regular use of medication
- •smoking, regular intake of alcohol or drugs
- •body mass index <18 or >30 kg/m2
- •previous intolerance of moderate altitude (<3000m)
结局指标
主要结局
apnea/hypopnea index
时间窗: day 1-4 at altitude
Reaction time
时间窗: day 1-4 at altitude
psychomotor vigilance test reaction time
次要结局
- Psychomotor vigilance(day 1-4 at altitude)
- arterial applanation tonometry(day 1-4 at altitude)
- sleep quality(day 1-4 at altitude)