NCT01308983Unknown4 期
Study of Amiloride on Vascular Phenotypes in Young Adults With Prehypertension
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Vascular phenotypes
研究概览
简要总结
Primary Specific Aim: To test the hypothesis that amiloride will improve vascular health of young adults with prehypertension.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Prehypertensive: Having systolic BP between 120 to 139 mmHg and/or diastolic BP between 80 to 89 mmHg during screening visit. BP will be measured manually tree times at 10 minutes interval after subjects sit quietly for at least 5 minutes in a chair. The average of last two BP measurements will be taken into consideration.
- •Male or female of Caucasian or African-American origin.
- •No history of any major past and current medical illness (such as diabetes, renal disease, liver disease etc.)
- •Not taking any medication that affects blood pressure.
排除标准
- •HbA1C > 7.0 % during screening visit.
- •Serum potassium > 5.5 mEq/L during screening and/or any testing visit due to risk of developing hyperkalemia.
- •Serum creatinine > 1.5 mg/100 ml and/or creatinine clearance < 50 ml/min* (Glomerular Filtration Rate Estimate by Abbreviated MDRD Study Equation)35 during screening and/or any testing visit due to risk of developing renal dysfunction.
- •Female having positive pregnancy test during screening and/or any testing visit.
研究组 & 干预措施
Amiloride
Other
干预措施: Amiloride (Drug)
结局指标
主要结局
Vascular phenotypes
时间窗: 16 weeks
(Flow mediated dilation, Pulse wave velocity, and carotid artery compliance)
次要结局
未报告次要终点
研究者
Yanbin Dong
Professor, Department of Pediatrics
Augusta University
研究点 (1)
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