Study of Amiloride on Vascular Phenotypes in Young Adults With Prehypertension
- Registration Number
- NCT01308983
- Lead Sponsor
- Augusta University
- Brief Summary
Primary Specific Aim: To test the hypothesis that amiloride will improve vascular health of young adults with prehypertension.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 32
Inclusion Criteria
- Prehypertensive: Having systolic BP between 120 to 139 mmHg and/or diastolic BP between 80 to 89 mmHg during screening visit. BP will be measured manually tree times at 10 minutes interval after subjects sit quietly for at least 5 minutes in a chair. The average of last two BP measurements will be taken into consideration.
- Male or female of Caucasian or African-American origin.
- No history of any major past and current medical illness (such as diabetes, renal disease, liver disease etc.)
- Not taking any medication that affects blood pressure.
Exclusion Criteria
- HbA1C > 7.0 % during screening visit.
- Serum potassium > 5.5 mEq/L during screening and/or any testing visit due to risk of developing hyperkalemia.
- Serum creatinine > 1.5 mg/100 ml and/or creatinine clearance < 50 ml/min* (Glomerular Filtration Rate Estimate by Abbreviated MDRD Study Equation)35 during screening and/or any testing visit due to risk of developing renal dysfunction.
- Female having positive pregnancy test during screening and/or any testing visit.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Amiloride Amiloride -
- Primary Outcome Measures
Name Time Method Vascular phenotypes 16 weeks (Flow mediated dilation, Pulse wave velocity, and carotid artery compliance)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Georgia Prevention Institute
🇺🇸Augusta, Georgia, United States