Post-ICU Covid19 Follow-up With Regards to Lung, Heart, Kidney and Cognitive Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 793
- 试验地点
- 1
- 主要终点
- Lung Function, end tidal Co2 in kPa
研究概览
简要总结
A follow up study of adult patients who have been treated in the ICU at Mölndal hospital due to Covid19 in the period of 2020 to 2022.
详细描述
The spread of Covid19 in the population in Sweden from 2019 and onwards posed new and serious strain on our ICU capacity. The disease presented with initially influenza like symptoms and evolved into multiorgan failure. 5% of all patients with verified Covid 19 were in need of critical care and among them the in-hospital mortality rate was 20%.
Patients will be followed up with after a minimum of three months after discharge from the ICU with regards to organ function.
Examinations within the scope of the study are;
- Comprehensive heart investigation including ultrasound
- Arterial blood gas and lung function tests including computer tomography of the lungs.
- Cognitive function with validated questioners
- Standardized test of physical function
- A panel of blood samples to assess organ function
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients treated at the Intensive Care Unit at Mölndals hospital from 2020 to 2022 for Covid19
- •More than 3 months passed since ICU discharge
- •Over 18 years of age at time of inclusion
- •Swedish resident with Swedish unique personal identification number.
- •Informed consent
排除标准
- •Under 18 years of age at time of inclusion
- •Not a Swedish resident
- •Unwillingness to participate
结局指标
主要结局
Lung Function, end tidal Co2 in kPa
时间窗: One year
Respiratory function following Covid19, end tidal carbon dioxide in kPa,
Cardiac biomarkers Troponin in ng/L
时间窗: One year
Cardiac function Blood sampling
Cardiac ultrasound
时间窗: One year
Cardiac ultrasound including ejection fractions (EF%)
Covid 19 antibodies
时间窗: One year
Antibodies IgG against Covid 19 lab test
Lung Function, complete arterial and venous blood gas in kPa
时间窗: One year
Respiratory function with arterial and venous blood gas pO2 and pCO2 in kPa
Lung Function oxygen saturation
时间窗: One year
Respiratory function following Covid19, saturation in SaO2%
Lung parenchym status
时间窗: One year
Ct scan of the lungs, assessed by radiology specialist, assessed for fibrosis, bronchiectasia and residual ground glass abnormalities
Cognitive function MMSE
时间窗: One year
Standardized cognitive tests
Cognitive function Montreal Cognitive Assessment
时间窗: One year
Standardized cognitive tests
Cognitive function CDR
时间窗: One year
Standardized cognitive tests,
Lung Function spirometry
时间窗: One year
Respiratory function with spirometry in Volumes in ml related to BMI
ECG
时间窗: One year
5 lead ECG for the detection av arrythmia
Cardiac biomarkers NTproBNPin ng/L
时间窗: One year
Cardiac function Blood sampling
Cognitive function biochemical markers
时间窗: One year
blood sampling with NFL, NSE, s-100B, fosfor-tau and APOE
Physical function
时间窗: One year
Standardized aggregate test of physical function, including seat raise test and grip strength measurement with validated instruments
Coagulation Status
时间窗: One year
Blood sampling Fibrinogen, D-Dimer, Antithrombin III and platelets, Aggregate variable to determine overall coagulation status
次要结局
- Frailty(One year)
- Return to own home(one year)
- Return to work(One year)
- New need for nursing assistance at home?(one year)
- Mental fatigue(One Year)
研究者
Bengt Nellgård
MD PhD Associate Professor
Sahlgrenska University Hospital