Clinical Outcomes of Preservation Versus Resection of Portal/Superior Mesenteric Vein During Pancreaticoduodenectomy in Pancreatic Cancer Patients Who Respond to Neoadjuvant Treatment
- Conditions
- Pancreatic Head Cancer Patients Who Underwent Surgery After Neoadjuvant Treatment
- Interventions
- Procedure: portal/superior vein resection
- Registration Number
- NCT06372886
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
1. There is a lack of evidence on the need to perform portal/superior mesenteric vein (PV/SMV) resection routinely in pancreatic ductal adenocarcinoma (PDAC) patients with venous involvement who responded to neoadjuvant treatment (NAT).
2. There is no significant differences in R0 rate, 5-year overall survival and recurrence-free survival between the PV/SMV preservation (PVP) group and PV/SMV resection (PVR) group.
3. PVP group showed significantly better 5-year PV/SMV stenosis free survival than the PVR group.
4. We propose that if dissection is possible and there is a high likelihood of achieving R0 resection after NAT, routine PVR may be unnecessary in PDAC patients with venous involvement.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 264
- Pancreatic head cancer patients who underwent surgery after neoadjuvant treatment between January 2012 and December 2022 at Seoul National University Hospital
- Metastatic unresectable and locally advanced pancreatic cancer
- Resectable pancreatic cancer without portal/superior mesenteric vein invasion
- Cancer aggravation after neoadjuvant treatment
- Portal/superior mesenteric vein encasing and narrowing after neoadjuvant treatment
- Patients who underwent palliative surgery
- Non-pancreatic ductal adenocarcinoma patients
- Patients who death within 30 days of surgery
- Loss of follow-up patients
- Patients who underwent resection for suspected main artery and adjacent organ invasion
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Preservation of portal/superior mesenteric vein portal/superior vein resection - Resection of portal/superior mesenteric vein portal/superior vein resection -
- Primary Outcome Measures
Name Time Method 5-year overall survival assessed up to 60months from diagnosis to any cause of death
5-year portal/superior mesenteric vein stenosis free survival assessed up to 60months from surgery to stenosis
- Secondary Outcome Measures
Name Time Method