Metabolic effects of morning light in obesity and type 2 diabetes

Completed

• Conditions: type 2 diabetes; 10018424

• Registration Number: NL-OMON38552
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2024-04-29

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 16

Inclusion Criteria

Group 1 (n<=8):
- age 18-80 years
- male sex
- BMI >25 kg/m2
- habitual wake-up time between 6:00 and 9:00
- no DM2: fasting venous plasma glucose <6.1 mmol/l and HbA1c <6.5%;Group 2 (n<=8):
- age 18-80 years
- male sex
- BMI >25 kg/m2
- habitual wake-up time between 6:00 and 9:00
- type 2 diabetes: fasting venous plasma glucose >6.9 mmol/l or HbA1c > 6.5%

Exclusion Criteria

- use of any other medication than metformin that interferers with glucose metabolism or neuronal synaptic transmission (corticosteroids, anti-depressants, anti-epileptic medication, other psychotropic drugs, anti malarials)
- gastro-intestinal or metabolic disease that will interfere with digestion or metabolism
- neuropsychiatric illness including severe depression
- epilepsy
- hypertension
- ophthalmological abnormalities (e.g. retinopathy)
- lactose intolerance
- soy allergy

Study & Design

• Study Type: Interventional
• Study Design: Not specified