Investigation of the Efficacies of a Resveratrol Formula on Improvement of Skin Conditions and Inflammatory Related Factors

Not Applicable

Completed

• Conditions: Skin Conditions; Proinflammatory Cytokines
• Interventions: Dietary Supplement: Resveratrol drink; Dietary Supplement: Placebo drink

• Registration Number: NCT04456829
• Lead Sponsor: TCI Co., Ltd.

Brief Summary

To assess a resveratrol formula on improvement of skin conditions and inflammatory cytokines in blood

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-06-30
• Study First Submitted QC: 2020-06-30
• Study First Posted: 2020-07-07
• Study Start: 2020-09-17
• Primary Completion: 2020-11-10
• Study Completion: 2020-12-31
• Status Verified: 2021-01
• Last Update Submitted: 2021-01-13
• Last Update Posted: 2021-01-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Healthy volunteers aged above 20 years old

Exclusion Criteria

• Subject who is not willing to participate in this study.
• Patients with diseases of the skin, heart, liver, kidney, endocrine and other organs and patients with mental illness (according to medical history).
• Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder.
• Female who is pregnant or nursing or planning to become pregnant during the course of the study.
• Received facial laser therapy, chemical peeling or UV overexposure in the past 4 weeks.
• Subjects who have large spots (area >3 square centimeter) or abnormal acne.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Resveratrol drink	Resveratrol drink	-
Placebo drink	Placebo drink	-

Primary Outcome Measures

Name	Time	Method
The change of IL-17 of blood	0 and 8 weeks	ELISA Kit
The change of skin collagen density	0, 4, and 8 weeks	DermaLab® USB - 20 MHz High Freq. Ultrasound probe was utilized to scan and analyze skin collagen density. Units: Intensity score
The change of TNF-alpha of blood	0 and 8 weeks	ELISA Kit
The change of skin moisture	0, 4, and 8 weeks	Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120
The change of skin elasticity	0, 4, and 8 weeks	Cutometer® dual MPA 580 was utilized to measure skin elasticity (parameter R2). Units: μm penetration depth into the probe opening, expressed as curves
The change of skin wrinkles	0, 4, and 8 weeks	VISIA Complexion Analysis System was utilized to measure wrinkles. Units: arbitrary units
The change of skin texture	0, 4, and 8 weeks	VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units
The change of total antioxidant capacity of blood	0 and 8 weeks	Total Antioxidant Capacity Assay Kit
The change of skin pores	0, 4, and 8 weeks	VISIA Complexion Analysis System was utilized to measure skin pores. Units: arbitrary units
The change of IL-6 of blood	0 and 8 weeks	ELISA Kit
The change of IL-1β of blood	0 and 8 weeks	ELISA Kit

Trial Locations

Locations (1)

Chia Nan University of Pharmacy & Science; 🇨🇳 Tainan City, Taiwan