Overexpression of CXCR4, CXCL12 and CXCR7 as a therapeutic approach to restore sensitivity to novel agents in multiple myeloma.
- Conditions
- C90.0Multiple myeloma
- Registration Number
- DRKS00009348
- Lead Sponsor
- niklinik Freiburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 130
Inclusion Criteria
Patients with multiple myeloma.
Exclusion Criteria
none
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Since the interaction of malignant plasma cells with the bone marrow is fundamental for multiple myeloma pathogenesis, the aim of our study was to analyze the CXCL12/CXCR4-axis and to examine the efficacy of targeting CXCR4/CXCL12 mediated adhesion to the bone marrow including effects on adhesion molecules.
- Secondary Outcome Measures
Name Time Method