Physical Endometrial Manipulation and Its Effect on Success Rate in Patients With Previous ICSI Failure
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Infertility
- Sponsor
- Aljazeera Hospital
- Enrollment
- 640
- Locations
- 1
- Primary Endpoint
- The number of participants who achieved clinical pregnancy
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Unexplained infertility is clinically diagnosed when there are no apparent or clear factors causing infertility on regular infertility assessment tools . Failure of implantation is a possible factor causing unexplained infertility . Implantation is the main rate limiting step in IVF outcome. Implantation is described at cellular and molecular level by adhesion or fixation of good quality embryo to receptive endometrium within a critical period of time which is called the window of implantation .
Detailed Description
Testing the effect of Physical manipulation of the endometrium on the quality of the endometrium prior to ICSI cycle and if it increases the success rate
Investigators
Mahmoud Alalfy
Mahmoud Alalfy
Aljazeera Hospital
Eligibility Criteria
Inclusion Criteria
- •Infertile female age 20-35 years
- •Previous Failed one ICSI trial
- •normal basal hormonal profile \[FSH, LH\] 3-10 mIU/ml and 1.8-8.5 mIU/ml respectively, --normal endometrial cavity
- •patent tubes
- •normal Husband semen analysis
Exclusion Criteria
- •Ovarian factor of infertility
- •Tubal factor of infertility
- •Endometrial factor of infertility
- •Male factor of infertility
Outcomes
Primary Outcomes
The number of participants who achieved clinical pregnancy
Time Frame: 6 weeks after embryo transfer
Describes how many participant will continue pregnancy after positive pregnancy test
Secondary Outcomes
- The number of participants who achieved ongoing pregnancy and live birth(9 months after embryo transfer)