Oral Candida in Infants and Dietary Type

Completed

• Conditions: Bottle Feeding; Oral Candida; Breastfeeding

• Registration Number: NCT01438983
• Lead Sponsor: Shahid Sadoughi University of Medical Sciences and Health Services

Brief Summary

This is an observational, non-randomised trial to evaluate the effect of dietary type on infants oral candida colonization the investigators evaluated 90 infants in 1-24 months (45 breastfeeding and 45 bottle feeding infants) who attended to Yazd clinic for regular pediatric appointment. Infants with unremarkable health histories, normal weight, free of sign or symptom of oral candidiasis or other mucosal disease. Their mothers were also healthy and without sign or symptom of vagina or mammary candidiasis. Pacifier usage, use of antibiotics in last months, sign or symptom of oral candidiasis in infants or vagina and mammary candidiasis in mothers were exclusion criteria.

Detailed Description

After filling in a questionnaire about infants dietary intake, age and sex and their mothers education level and health condition, a pre-moistened sterile cotton swab was taken from dorsal surface of tongue and mid-plate. The swabs were cultured in agar plate containing sabourauds dextrose agar medium with chloramphenicol, and kept in 37 C for 48 hours. The number of candida colonies was counted and germ tube test performed to separate candida albicans from other types. The data was collected and analyzed by SPSS software and chi-square, logistic regression and mann-whitney test. Study hypothesis: feeding by mothers milk reduces oral candida colonization.

Study Timeline

• Study Start: 2009-07
• Study Completion: 2010-06
• Status Verified: 2011-09
• Study First Submitted: 2011-09-18
• Study First Submitted QC: 2011-09-21
• Last Update Submitted: 2011-09-21
• Study First Posted: 2011-09-22
• Last Update Posted: 2011-09-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• healthy infants
• healthy mothers

Exclusion Criteria

• pacifier usage
• use of antibiotics in last month
• sign or symptom of oral candidiasis in infants
• vagina and mammary candidiasis in mothers

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
mean number of candida colonies	6 months	number of candida colonies growth in agar plate

Secondary Outcome Measures

Name	Time	Method
prevalence of oral candida colonization in infants according to age and sex	6 months	exist of candida colony in agar plate

Trial Locations

Locations (1)

Nastaran Azimi; 🇮🇷 Yazd, Iran, Islamic Republic of