Change in Airway Responsiveness After Allergen Exposure
Not Applicable
Completed
- Conditions
- Allergic Asthma
- Interventions
- Registration Number
- NCT01699594
- Lead Sponsor
- University of Saskatchewan
- Brief Summary
Exposure to allergens changes the way the airway responds to some stimuli (methacholine). The investigators will look at whether or not exposure to allergens changes the way the airway responds to a different stimuli (mannitol) and compare that with the known stimuli (methacholine).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 11
Inclusion Criteria
- mild, allergic asthma
- FEV1 greater than 70% predicted
- methacholine PC20 less than or equal to 16mg/ml
Exclusion Criteria
- known sensitivity to mannitol or other excipient
- diagnosis of any other respiratory or non respiratory disease/disorder that would preclude the individual from participating
- recent thoracic, abdominal or eye surgery
- recent allergen exposure (4 weeks), respiratory infection (6 weeks)
- current immunotherapy
- pregnancy
- history of anaphylaxis
- use of asthma therapies other than short acting beta agonist
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Mannitol Mannitol This arm will assess the allergen induced change in airway responsiveness to mannitol bronchoprovocation. Methacholine Chloride Methacholine Chloride This arm will assess the allergen induced change in airway responsiveness to methacholine bronchoprovocation.
- Primary Outcome Measures
Name Time Method Change from baseline in airway responsiveness three hours after allergen exposure Change from Baseline at 3 hours
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link allergen exposure to increased indirect non-allergic bronchial reactivity in allergic asthma?
How does mannitol-induced bronchial reactivity compare to methacholine in assessing airway hyperresponsiveness in allergic asthma patients?
Which biomarkers are associated with allergen-induced changes in airway responsiveness to non-allergic stimuli in allergic asthma?
What adverse events are reported with mannitol and methacholine in clinical trials for allergic asthma management?
Are there combination therapies involving mannitol or methacholine that enhance allergen-induced bronchial reactivity outcomes in allergic asthma?
Trial Locations
- Locations (1)
University of Saskatchewan
🇨🇦Saskatoon, Saskatchewan, Canada
University of Saskatchewan🇨🇦Saskatoon, Saskatchewan, Canada