NCT01699594已完成不适用
Allergen Induced Increase in Indirect Non-allergic Bronchial Reactivity
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 1
- 主要终点
- Change from baseline in airway responsiveness three hours after allergen exposure
研究概览
简要总结
Exposure to allergens changes the way the airway responds to some stimuli (methacholine). The investigators will look at whether or not exposure to allergens changes the way the airway responds to a different stimuli (mannitol) and compare that with the known stimuli (methacholine).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •mild, allergic asthma
- •FEV1 greater than 70% predicted
- •methacholine PC20 less than or equal to 16mg/ml
排除标准
- •known sensitivity to mannitol or other excipient
- •diagnosis of any other respiratory or non respiratory disease/disorder that would preclude the individual from participating
- •recent thoracic, abdominal or eye surgery
- •recent allergen exposure (4 weeks), respiratory infection (6 weeks)
- •current immunotherapy
- •pregnancy
- •history of anaphylaxis
- •use of asthma therapies other than short acting beta agonist
研究组 & 干预措施
Mannitol
Experimental
This arm will assess the allergen induced change in airway responsiveness to mannitol bronchoprovocation.
干预措施: Mannitol (Drug)
Methacholine Chloride
Active Comparator
This arm will assess the allergen induced change in airway responsiveness to methacholine bronchoprovocation.
干预措施: Methacholine Chloride (Drug)
结局指标
主要结局
Change from baseline in airway responsiveness three hours after allergen exposure
时间窗: Change from Baseline at 3 hours
次要结局
未报告次要终点
研究者
研究点 (1)
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