Neuronal and Behavioral Effects of an Implicit Priming Approach to Improve Eating Behaviors in Obesity

Not Applicable

Recruiting

• Conditions: Overweight and Obesity

• Registration Number: NCT05107908
• Lead Sponsor: University of Colorado, Denver

Brief Summary

The purpose of this study is to determine how different behavioral interventions designed to alter food perceptions and behaviors affect brain responses to food, eating behaviors, and body weight.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-11-03
• Study First Submitted QC: 2021-11-03
• Study First Posted: 2021-11-04
• Study Start: 2021-11-12
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-21
• Last Update Posted: 2025-04-22
• Primary Completion: 2026-03
• Study Completion: 2026-03

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 228

Inclusion Criteria

• 18-65 years old
• BMI of 27 or greater

Exclusion Criteria

• MRI contraindications (e.g., metal or electronic devices in the body)
• Pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Percent Change in Blood Oxygen Level Dependent (BOLD) Response to Visual Food Cues as Measured by Functional Magnetic Resonance Imaging	Baseline, 12 weeks	Percent change in blood oxygen level dependent (BOLD) response from baseline to after the 12-week intervention while viewing visual food cues will be measured using functional magnetic resonance imaging (fMRI), focusing on insula, striatum, and prefrontal cortex.
Change in Food Image Ratings	Baseline, 12 weeks	Food image ratings change from baseline to after the 12-week intervention. Food images are rated on "desire to eat" by visual analogue scale (0-100), with higher scores indicating greater desire to eat.
Change in Food Intake	Baseline, 12 weeks	Food intake change from baseline to after the 12-week intervention. Food intake will be measured as total calories consumed during an ad libitum meal.

Secondary Outcome Measures

Name	Time	Method
Percent Change in Body Weight	Baseline, 12 weeks	Percent change in body weight (kg) from baseline to after the 12-week intervention.
Change in Fat Mass	Baseline, 12 weeks	Change in fat mass, as measured using dual-energy x-ray absorptiometry, from baseline to after the 12-week intervention.

Trial Locations

Locations (1)

University of Colorado Anschutz Medical Campus; 🇺🇸 Aurora, Colorado, United States