Neuronal and Behavioral Effects of an Implicit Priming Approach to Improve Eating Behaviors in Obesity

Not Applicable

Recruiting

• Conditions: Overweight and Obesity
• Interventions: Behavioral: Control Implicit Priming; Behavioral: Active Implicit Priming; Behavioral: Food Exposure Task

• Registration Number: NCT05107908
• Lead Sponsor: University of Colorado, Denver

Brief Summary

The purpose of this study is to determine how different behavioral interventions designed to alter food perceptions and behaviors affect brain responses to food, eating behaviors, and body weight.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-11-03
• Study First Submitted QC: 2021-11-03
• Study First Posted: 2021-11-04
• Study Start: 2021-11-12
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-02
• Last Update Posted: 2024-02-05
• Primary Completion: 2025-12
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 228

Inclusion Criteria

• 18-65 years old
• BMI of 27 or greater

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Exclusion Criteria

• MRI contraindications (e.g., metal or electronic devices in the body)
• Pregnancy

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control Implicit Priming	Control Implicit Priming	Participants will complete control implicit priming, which matches the active intervention, but with neutral stimuli as primes. This will be completed on a weekly basis for 12 weeks, for approximately 10 minutes each time.
Active Implicit Priming	Active Implicit Priming	Participants will complete active implicit priming, in which food images are implicitly primed (i.e., below conscious awareness) with images of positive or negative affect. This will be completed on a weekly basis for 12 weeks, for approximately 10 minutes each time.
Food Exposure Task	Food Exposure Task	Participants will complete a Food Exposure Task, in which they will be asked to smell, feel, lick, and imagine eating food items, but without actually eating them. This will be completed on a weekly basis for 12 weeks, for approximately 10-30 minutes each time.

Primary Outcome Measures

Name	Time	Method
Percent Change in Blood Oxygen Level Dependent (BOLD) Response to Visual Food Cues as Measured by Functional Magnetic Resonance Imaging	Baseline, 12 weeks	Percent change in blood oxygen level dependent (BOLD) response from baseline to after the 12-week intervention while viewing visual food cues will be measured using functional magnetic resonance imaging (fMRI), focusing on insula, striatum, and prefrontal cortex.
Change in Food Image Ratings	Baseline, 12 weeks	Food image ratings change from baseline to after the 12-week intervention. Food images are rated on "desire to eat" by visual analogue scale (0-100), with higher scores indicating greater desire to eat.
Change in Food Intake	Baseline, 12 weeks	Food intake change from baseline to after the 12-week intervention. Food intake will be measured as total calories consumed during an ad libitum meal.

Secondary Outcome Measures

Name	Time	Method
Percent Change in Body Weight	Baseline, 12 weeks	Percent change in body weight (kg) from baseline to after the 12-week intervention.
Change in Fat Mass	Baseline, 12 weeks	Change in fat mass, as measured using dual-energy x-ray absorptiometry, from baseline to after the 12-week intervention.

Trial Locations

Locations (1)

University of Colorado Anschutz Medical Campus; 🇺🇸 Aurora, Colorado, United States