Sex or no Sex: That is the Question.

Recruiting

• Conditions: Infertility, Female; Sexual Intercourse

• Registration Number: NCT04880590
• Lead Sponsor: Fundación Santiago Dexeus Font

Brief Summary

This study aims to evaluate the impact of sexual intercourse and orgasm in the 72 hrs following embryo transfer of blastocysts on the clinical pregnancy rate.

An impact on sexual activity and a decrease in the frequency of intercourse has been observed in infertile couples. In couples who undergo assisted reproductive technology (ART), sexual relations have an additional component that can condition them, such as the fear of influencing the outcome of the cycle.

The usual practice in ART cycles has evolved towards a preference for blastocyst-stage embryo transfer, both in fresh in vitro fertilization (IVF) cycles and in frozen embryo transfer (FET) cycles.

The investigators consider it important to elucidate whether coital intercourse after embryo transfer (ET) has an impact on the clinical pregnancy rate after the transfer of blastocyst-stage embryos.

Detailed Description

It is proposed to carry out an observational, prospective study, in which women with a heterosexual sexual relationship are included, who carry out an embryo transfer, in a FET cycle in the Dexeus Woman Reproduction Medicine Service and who agree to participate in the same.

Study Timeline

• Study Start: 2021-05-04
• Study First Submitted: 2021-05-05
• Study First Submitted QC: 2021-05-05
• Study First Posted: 2021-05-11
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-10
• Last Update Posted: 2025-03-11
• Primary Completion: 2025-11
• Study Completion: 2026-02

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 2500

Inclusion Criteria

• Women with a heterosexual sexual relationship
• That they carry out an embryo transfer, in a FET cycle

Exclusion Criteria

• Exclusion criteria are not foreseen

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical pregnancy rate	6-7 weeks after transfer	Clinical pregnancy rate measured by ultrasound with the presence of a positive fetal heartbeat

Secondary Outcome Measures

Name	Time	Method
Miscarriage rate	Until 13 weeks after embryo transfer procedure	The loss of a pregnancy during the first 13 weeks of pregnancy
Live birth rate	Until 42 weeks after embryo transfer	Number of live birth after embryo transfer

Trial Locations

Locations (1)

Hospital Universitario Quiron Dexeus; 🇪🇸 Barcelona, Spain