The multicenter study for purposes of detection of prognostic factor of advanced stage pediatric lymphoblastic lymphoma treated with standard chemotherapy
Not Applicable
- Conditions
- lymphoblastic lymphoma stage III / IV
- Registration Number
- JPRN-UMIN000018780
- Lead Sponsor
- Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 92
Inclusion Criteria
Not provided
Exclusion Criteria
(1) Down syndrome. (2) Other previous illness of malignant tumor or previous therapy of organ transplantation including hematopoietc stem cells. (3) history of congenital or acquired immunodeficiency. (4) uncontrolled infection, including active tuberculosis infection and positive of HIV antibody. (5) pregnancy or high possibility of pregnancy and giving suck woman. (6) QTfc, corrected by Friderics formula as QTfc = QT/RR*1/3, is more than 0.45 seconds. (7) CNS hemorrage more than grade 3 of CACAE v4.0 (8) MDS, Ph1 positive (9) any inappropriate status judged by physician.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The ratio of cases with 6qLOH in T-cell lymphoblastic lymphoma and hazard ratio in 3-year event free survival
- Secondary Outcome Measures
Name Time Method The ratio of cases with positive minimal disseminated disease (MDD) in T or B-cell lymphoblastic lymphoma and each hazard ratio in 3-year event free survival