Growth Hormone Adjuvant Therapy With Long Down Regulation Protocol in Poor Responders Undergoing In Vitro Fertilization Cycles: a Randomized Control Trial
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 240
- 试验地点
- 1
- 主要终点
- Live birth rate
研究概览
简要总结
The long down regulation protocol is widely used in the in vitro fertilization cycles, now it will be assessed regarding its efficacy, in poor responder females undergoing in vitro fertilization cycles, alone and after the addition of growth hormone.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 44 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Poor responder females are those who posses two out of these three criteria:
- •Female age ≥40 years
- •Females who have at least one previous cancelled IVF cycle
- •POR according to AFC ≤ 5 or low AMH value.
排除标准
- •Females over 45 years
- •Females with FSH more than 20 IU/l
- •Females with previous ovarian surgery
- •Females suffering from causes of infertility other than poor ovarian response
- •Females refusing to be enrolled in the study
研究组 & 干预措施
Long + Growth hormone
Patients in this group were given a long protocol of pituitary down-regulation with triptorelin (Decapeptyl; Ferring, Switzerland) starting on the day 21 of preceding cycle at a dose of 0.1 mg/day, subcutaneously along with Growth hormone (Norditropin, Novo nordisk) co-treatment daily in a dose of 2.5 mg S.C. till the day of hCG administration.. On the second day of menstruation, Human menopausal gonadotrophin HMG (75 IU, Merional, IBSA) was started, and this was associated with reduction of triptorelin dose to 0.05 mg/day. This reduced daily dose, in addition to HMG and growth hormone, were continued till the day of hCG administration.
干预措施: Growth hormone (Drug)
结局指标
主要结局
Live birth rate
时间窗: 12 months
Fresh, Frozen, Cumulative
次要结局
未报告次要终点
研究者
Dina Mohamed Refaat Dakhly
lecturer of obstetrics and gynecology
Woman's Health University Hospital, Egypt