Effect of polysaturated fatty acids on vascular healing process in hyper-cholesterolemic patients with acute coronary syndrome
Not Applicable
- Conditions
- acute coronary syndrome
- Registration Number
- JPRN-UMIN000012825
- Lead Sponsor
- Department of Cardiovascular Medicine Nara Medical University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 180
Inclusion Criteria
Not provided
Exclusion Criteria
Patients meeting all of the following criteria will be excluded. 1) patients who had been taking EPA or EPA+DHA before enrollment 2) bleeding tendency 3) hypersensitivity for EPA or EPA+DHA 4) congestive heart failure 5) refractory unstable angina 6) participating other clinical trials 7) pregnant, lactating, and possibly pregnant women and those planning to become pregnant 8) judged as ineligible by clinical investigators
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in OCT parameter at 8-month follow-up 1) thickness of fibrous cap at non-culprit lipid rich plaque 2) condition of neointimal coverage over implanted stent
- Secondary Outcome Measures
Name Time Method Changes in following paremter at 8-month follow-up 1) lipid core size (OCT) 2) serum plasma profile 3) changes in inflammatory parameters 4) relation between lipid core size and serum lipid profile Changes in following paremter at 12-month follow-up 5) serum lipid profile 6) development of adverse cardiovascular events