Mannelijke vruchtbaarheid na een hoge dosis radioactief jodium voor de behandeling van gedifferentieerd schildklierkanker
Recruiting
- Conditions
- Differentiated thyroid cancer (DTC/Gedifferentieerd schildkliercarcinoomMale fertility/Mannelijke fertiliteitRadioactive iodine/Radioactie jodium
- Registration Number
- NL-OMON23189
- Lead Sponsor
- niversity Medical Center Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
All males (age ¡Ý 18y) diagnosed with DTC in the Netherlands from January 2008 that are at least ¡Ý2 years after their last treatment with a high cumulative dose of radioiodine (¡Ý 100 mCi/3.7 GBq) are eligible for inclusion.
Exclusion Criteria
A potential subject who meets any of the following criteria will be excluded from participation in this study:
- Use of drugs that interact with semen quality (i.e. testosterone suppletion, chemotherapy);
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Semen concentration
- Secondary Outcome Measures
Name Time Method Semen quality, measured by means of the following parameters:<br /><br>-Volume<br /><br>-Concentration<br /><br>-Motility<br /><br>-Morphology<br /><br>-VCM<br /><br>-pH<br /><br>- Serum endocrine markers:<br /><br>- LH <br /><br>- FSH<br /><br>- Free T<br /><br>-Conceived pregnancies/pregnancy complications/congenital malformations in children<br /><br>-Ongoing pregnancy (>12 weeks) and live birth rate<br /><br>-Data regarding semen quality before radioiodine administration<br /><br>-Number of patients performing semen preservation and subsequent usage rate<br /><br>-To evaluate sexual health in males treated with radioiodine for DTC.<br /><br>