Full Assessment of Clinical Transfusion Support

Completed

• Conditions: Sickle Cell Anemia; Blood Transfusion; Malaria Parasitaemia

• Registration Number: NCT07094646
• Lead Sponsor: Children's Hospital Medical Center, Cincinnati

Brief Summary

This study looks at why some children develop very severe anemia that leads to a blood transfusion. It also checks for diseases in the blood they receive. Researchers are using small samples of dried blood (called dried blood spots) from both the children and the donated blood to find out what might be causing the anemia.

Detailed Description

This study includes children at Jinja Regional Referral Hospital (Jinja, Uganda) who need a blood transfusion, whether they are in the clinic, emergency room, or children's ward. After doctors finish the usual blood tests, a small sample of leftover blood will be saved on a special card (called a dried blood spot). The same will be done for all blood transfused during the study. These samples will be frozen and later sent to Cincinnati Children's Hospital for testing.

Study Timeline

• Study Start: 2023-09-21
• Primary Completion: 2024-03-19
• Study Completion: 2024-03-19
• Status Verified: 2025-07
• Study First Submitted: 2025-07-23
• Study First Submitted QC: 2025-07-23
• Last Update Submitted: 2025-07-23
• Study First Posted: 2025-07-30
• Last Update Posted: 2025-07-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

• Children receiving a blood transfusion in Eastern Uganda at Jinja Regional Referral Hospital.

Exclusion Criteria

• If receiving a blood transfusion, refusal or inability to sign an informed consent.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Frequency of Sickle Cell Anemia	At enrollment.	How common sickle cell anemia is in children who need a blood transfusion in Eastern Uganda.

Secondary Outcome Measures

Name	Time	Method
Frequency of Malaria Parasitemia	At enrollment.	How common malaria parasitemia in children needing blood transfusions in Eastern Uganda.
Frequency of Iron Deficiency	At enrollment	How often people who get blood transfusions have low iron levels, and the iron levels in the blood that is donated and used for transfusions
Blood Group Markers	At enrollment.	Checking to ensure safe blood matches from donated blood and people receiving blood transfusions.

Trial Locations

Locations (1)

Jinja Regional Referral Hospital (JRRH); 🇺🇬 Jinja, Uganda