Italian Registry on the Prevalence of IDH1/IDH2 Mutations in Patients With Acute Myeloid Leukemia
- Conditions
- AML, Adult
- Interventions
- Genetic: IDH mutation test performed at diagnosis or relapse until January 31st, 2019.
- Registration Number
- NCT02986620
- Brief Summary
This is a study where there are no interventions planned. Investigators will only collect data already in the patient's history and analyze it. Particularly, we are interested in molecular data from AML patients.
This means that patients will follow their regular diagnostic and clinical practice. The analyses will be conducted according to the routine diagnostic and clinical practice as well and no additional blood withdrawal will be performed.
- Detailed Description
The study will be conducted as follows:
1. Retrospective phase clinical and molecular data of patients analyzed for IDH1/2 mutations will be retrospectively collected in the centers that have already introduced IDH1/2 mutational screening in their practice from cases collected according to standard procedure (Ficoll and lysis in RLT buffer).
2. Prospective phase: each participating center already performing IDH1/2 mutational status on samples of their AML patients at diagnosis or relapse - on freshly isolate mononuclear cells from bone marrow and/or peripheral blood using Ficoll density gradient preparation - will prospectively collect the clinical and molecular data.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 388
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description AML patients IDH mutation test performed at diagnosis or relapse until January 31st, 2019. Adult AML patients with the IDH mutation test performed at diagnosis or relapse until January 31st, 2019.
- Primary Outcome Measures
Name Time Method Number of patients with the IDH mutations in AML at initial diagnosis. At two years from study entry. Number of patients with the IDH mutations in AML at relapse. At three years from study entry.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (24)
AOU Policlinico G. Martino
🇮🇹Messina, Italy
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico UOC Oncoematologia- Padiglione Marcora 2° piano
🇮🇹Milano, Italy
Università degli Studi di Padova - Ematologia ed Immunologia Clinica
🇮🇹Padova, Italy
Ente Ecclesiastico Casa Sollievo Della Sofferenza - San Giovanni Rotondo - Ematologia
🇮🇹San Giovanni Rotondo, Italy
Asui Di Udine - Presidio Ospedaliero "Santa Maria Della Misericordia" - Clinica Ematologica
🇮🇹Udine, Italy
I.R.S.T. Srl Irccs - Meldola - Sc Oncologia Medica
🇮🇹Meldola, Italy
AU Policlinico "Paiolo Giaccone"
🇮🇹Palermo, Italy
Sezione di ematologia ed immunologia - Clinica Ospedale S. Maria della Misericordia
🇮🇹Perugia, Italy
Asl Brindisi, Ospedale 'Perrino' - Brindisi - Uo Ematologia
🇮🇹Brindisi, Italy
IFO Istituto Nazionale Tumori Regina Elena
🇮🇹Roma, Italy
UO Ematologia _AOU Policlinico di Modena
🇮🇹Modena, Italy
Ao Ospedali Riuniti Villa Sofia Cervello - Palermo - Uo Ematologia Con Utmo
🇮🇹Palermo, Italy
Università Cattolica del Sacro Cuore - Policlinico A.Gemelli
🇮🇹Roma, Italy
Aon Ss. Antonio E Biagio E C. Arrigo - Alessandria - Soc Ematologia
🇮🇹Alessandria, Italy
Aou Consorziale Policlinico - Bari - Uo Ematologia Con Trapianto
🇮🇹Bari, Italy
Asst Grande Ospedale Metropolitano Niguarda - Milano - Sc Ematologia
🇮🇹Milano, Italy
Istituto Europeo Di Oncologia Irccs - Milano - Divisione Di Oncoematologia
🇮🇹Milano, Italy
Aou Di Parma - Sc Ematologia E Centro Trapianti Midollo Osseo
🇮🇹Parma, Italy
Asl Di Piacenza, Ospedale "Guglielmo Da Saliceto" - Ematologia E Centro Trapianti
🇮🇹Piacenza, Italy
Università degli Studi - Policlinico di Tor Vergata
🇮🇹Roma, Italy
Università degli Studi - Policlinico Tor Vergata
🇮🇹Rome, Italy
Istituto di Ematologia "Lorenzo e A. Seragnoli" - Università degli Studi di Bologna - Policlinico S. Orsola - Malpighi
🇮🇹Bologna, Italy
Aou Di Bologna - Policlinico S. Orsola-Malpighi - Uoc Ematologia
🇮🇹Bologna, Italy
Irccs Ospedale S. Raffaele - Milano - Uo Oncoematologia
🇮🇹Milano, Italy