Efficacy of NSAID transdermal patch in postoperative total knee arthroplasty patients with multimodal analgesia and perioperative intravenous dexamethasone

Phase 1

• Conditions: Osteoarthritis of knee; Osteoarthritis knee nsaids patch transdermal dexamethasone

• Registration Number: TCTR20230907003
• Lead Sponsor: Faculty of Medicine Ramathibodi Hospital, Mahidol University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-09-07
• Last Update Posted: 19 August 2024
• Study Completion: 2024-09-09

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

1.Age 55-80 years old
2.KL 3-4
3.Primary Total Knee Arthroplast
4.Willing to join research

Exclusion Criteria

1. Allergic to Steroids, NSAIDs, Morphine, Paracetamol, Gabapentinoids, or Codeine
2.GFR less than 30 mL/min/1.73m2
3.DM with HbA1C > 8 mg%
4.Previous Steroids used regularly or continuous over 1 month
5.cannot anaesthetised by spinal block alone
6.not willingly to join the research

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
VAS 2 wk, 6 wk, 3 mo point 0-10

Secondary Outcome Measures

Name	Time	Method
KOOS 2 wk, 6 wk, 3 mo point