The Effects of Exercise on Appetite Regulation in Overweight/Obese Individuals
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 69
- 试验地点
- 2
- 主要终点
- fMRI Response to Visual Food Cues
研究概览
简要总结
In this study the Investigators are examining the effects of a 12-week exercise program (intervention) on measures of appetite and food intake regulation in overweight to mildly obese healthy adults. The Investigators hypothesize that individuals who lose a significant amount of weight in response to the intervention will show a reduction in the brain response to food cues as measured by functional magnetic resonance imaging (fMRI) when compared to those who do not lose weight. These changes in neuronal activity will be associated to physiologic and behavioral measures.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •all ethnic groups and both genders;
- •age: 21-45 yrs;
- •BMI: 27-35;
- •weight stable within +/- 5 percent in the last 6 months;
- •sedentary (less than 1 hour of planned physical activity by self-report).
排除标准
- •history of cardiovascular disease (CVD), diabetes mellitus, uncontrolled hypertension, untreated thyroid disease, renal disease, hepatic disease, or any other medical condition affecting weight or energy metabolism;
- •unable to effectively exercise due to cardiac, pulmonary, neurologic or orthopedic reasons;
- •unable to pass screening graded exercise treadmill test;
- •currently smoking;
- •medications affecting weight, Energy Intake (EI) or Energy Expenditure (EE) in the last 6 months;
- •weight loss or weight gain of >5 percent in past 6 months;
- •currently pregnant, lactating or less than 6 months post-partum;
- •bariatric surgery;
- •major psychiatric disorder, presence of alcohol or substance abuse, current depression by history and/or a score >21 on the he Center for Epidemiologic Studies Depression Scale (CES-D), history of eating disorders and/or a score of >20 on the EATS-26;
- •contraindication to MRI
结局指标
主要结局
fMRI Response to Visual Food Cues
时间窗: 12 weeks
The neuronal response will be assessed by functional magnetic resonance imaging (fMRI) in response to visual food cues Blood oxygen dependent signal (BOLD) response in exposure to visual food cues will be measured during a fMRI scan and the difference between responses in those who lose weight vs. those who do not lose weight will be compared.
次要结局
未报告次要终点