NL-OMON37250已完成2 期
Prophylactic infusion of CD4 positive donor lymphocytes early after T-cell depleted allogeneic stem cell transplantation in patients with an unrelated donor - CD4+ donor lymphocytes
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Age > 18 years
- •Patients with AML, myelodysplasia , ALL, CML in accelerated phase or blastic transformation, CLL, MM or (non) Hodgkin lymphoma, who underwent an allo-SCT with an unrelated 10/10 matched donor (matched for HLA-A, B, C, DR and DQ)
- •Life expectation of > 3 months
- •WHO performance status of 0, 1 or 2
- •Written informed consent according to the rules and regulations of the Leiden University Medical Center.
排除标准
- •Use of systemic immunosuppressive treatment (due to GVHD)
- •Acute GVHD of the skin > grade 2 or progressive acute GVHD
- •Progressive disease needing cytoreductive treatment
- •Any concomitant disease preventing the safe administration of donor lymphocytes
- •Severe psychological disturbances
- •Severely limited life expectation due to diseases other than the malignancy
- •Very high risk disease preceding allo-SCT for which already unselected DLI is planned to be given 3 months after allo-SCT.
研究者
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