The effect of probiotic on the weight gaining and feeding intolerance in preterm newborn babies of Kabul city via a randomized clinical trial

Not Applicable

Completed

• Conditions: Prematurity; Low birth weight; slow weight gaining; Diet and Nutrition - Other diet and nutrition disorders; Reproductive Health and Childbirth - Complications of newborn

• Registration Number: ACTRN12620000538943
• Lead Sponsor: Professor Mansoor Aslamzai, MD

Brief Summary

1. Research question: Does dual strain probiotics increase the weight gaining and feeding intolerance of preterm neonates? 2. Background information: Prematurity is prevalent worldwide and accounts for the leading cause of neonatal death. Slow weight gain, feeding intolerance, prolong hospital stay, and high mortality are significant issues for preterm neonates. Dual strain probiotics can manage such complications of prematurity. 3. Participant characteristics: Preterm neonates with the gestational age of equal or less than 36 weeks or weight less than 2000g. 4. Key results: Dual strain probiotics significantly improved the daily weight gain of premature neonates. However, probiotics also decreased the risks of feeding intolerance and death during the hospital stay but these findings were not statistically significant.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-05-01
• Study Completion: 2021-02-26
• Last Update Posted: 20 September 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 107

Inclusion Criteria

Preterm neonates fulfill one of the following criteria’s will be enrolled in the study.
1- Gestational age of equal or less than 35weeks.
2- Weight less than 2000g.

Exclusion Criteria

Neonates have visible or physically detected malformation, birth weight less than 1000gr, severe birth asphyxia, seriously ill baby and parent who declined consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified