International Sarcoma Kindred Study: Identification of inherited risk in individuals with sarcoma

Not Applicable

Recruiting

• Conditions: sarcoma; genetic mutations; Cancer - Sarcoma (also see 'Bone') - soft tissue; Human Genetics and Inherited Disorders - Other human genetics and inherited disorders

• Registration Number: ACTRN12610000120077
• Lead Sponsor: Australasian Sarcoma Study Group

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-02-04
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 3000

Inclusion Criteria

All those diagnosed with sarcoma are eligible for inclusion. Controls must be age matched within 5 years of the proband, be older than or equal to 18 years of age, not have had a cancer diagnosis and not be a blood relative.

Exclusion Criteria

Controls must be older than or equal to 18 years of age

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Creation of a research resource consisting of biospecimens and associated clinical data and information from 3000 individuals and their families[ At 7 years from commencement of the study];Development of clinically useful population based criteria for stratifying genetic or hereditary risk for adult-onset sarcoma[ At 7 years from commencement of the study];Mapping genetic mutations in patients with adult-onset sarcoma using linkage analysis and next generation sequencing[ At 2-5 years from the commencement of the study]

Secondary Outcome Measures

Name	Time	Method
Evaluation of community attitudes to genetic research and testing in the setting of sarcoma using a questionnaire[ At 2-3 years from the commencement of the study]