NCT00889031
Completed
Not Applicable
Protocol to Obtain Blood Samples for Leukemia Research
ConditionsChronic Lymphocytic Leukemia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Lymphocytic Leukemia
- Sponsor
- Dartmouth-Hitchcock Medical Center
- Enrollment
- 187
- Locations
- 1
- Primary Endpoint
- To determine the frequency with which CLL cells incubated ex vivo with vincristine undergo rapid interphase apoptosis.
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The purpose of this study is to collect a blood sample in patients with Chronic Lymphocytic Leukemia (CLL).
Detailed Description
The blood sample will be used in the laboratory to perform studies focusing on Chronic Lymphocytic Leukemia (CLL).
Investigators
Christopher H. Lowrey
Professor of Medicine and of Pharmacology and Toxicology
Dartmouth-Hitchcock Medical Center
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing routine blood draws as part of their ongoing follow-up for Chronic Lymphocytic Leukemia (CLL) at the Norris Cotton Cancer Center of DHMC.
Exclusion Criteria
- •Patients who have received cytotoxic drug, oral or intravenous steroid or targeted antibody therapy for CLL or other disease process within the past 6 months are excluded. Use of intravenous immunoglobulin (IVIg) is not a reason for exclusion.
Outcomes
Primary Outcomes
To determine the frequency with which CLL cells incubated ex vivo with vincristine undergo rapid interphase apoptosis.
Time Frame: 2 Years
Secondary Outcomes
- To determine whether suppression or inhibition of BCL2 family members can acutely sensitize CLL cells to vincristine.(2 Years)
Study Sites (1)
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