NCT00889031CompletedNot Applicable
Protocol to Obtain Blood Samples for Leukemia Research
Dartmouth-Hitchcock Medical Center1 site in 1 country187 target enrollmentStarted: April 2009Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 187
- Locations
- 1
- Primary Endpoint
- To determine the frequency with which CLL cells incubated ex vivo with vincristine undergo rapid interphase apoptosis.
Study Overview
Brief Summary
The purpose of this study is to collect a blood sample in patients with Chronic Lymphocytic Leukemia (CLL).
Detailed Description
The blood sample will be used in the laboratory to perform studies focusing on Chronic Lymphocytic Leukemia (CLL).
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients undergoing routine blood draws as part of their ongoing follow-up for Chronic Lymphocytic Leukemia (CLL) at the Norris Cotton Cancer Center of DHMC.
Exclusion Criteria
- •Patients who have received cytotoxic drug, oral or intravenous steroid or targeted antibody therapy for CLL or other disease process within the past 6 months are excluded. Use of intravenous immunoglobulin (IVIg) is not a reason for exclusion.
Outcomes
Primary Outcomes
To determine the frequency with which CLL cells incubated ex vivo with vincristine undergo rapid interphase apoptosis.
Time Frame: 2 Years
Secondary Outcomes
- To determine whether suppression or inhibition of BCL2 family members can acutely sensitize CLL cells to vincristine.(2 Years)
Investigators
Christopher H. Lowrey
Professor of Medicine and of Pharmacology and Toxicology
Dartmouth-Hitchcock Medical Center
Study Sites (1)
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