NCT06245785已完成不适用
Liver Resection for Patients With Hepatocellular Carcinoma and Impaired Liver Function: A Chinese Multicenter Observational Study
Tang-Du Hospital2 个研究点 分布在 1 个国家目标入组 2,200 人开始时间: 2023年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 2,200
- 试验地点
- 2
- 主要终点
- overall survival
研究概览
简要总结
Hepatic dysfunction limits the therapeutic options for hepatocellular carcinoma (HCC), which is closely associated with patient prognosis. Established practice guidelines for patients with HCC and impaired liver function are lacking. The treatment allocation in these populations is heterogeneous and remains controversial. This study compared the survival benefits of liver resection (LR) and transarterial chemoembolisation (TACE) in patients with HCC and impaired liver function.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with HCC who received conventional LR or TACE
排除标准
- •（1） presence of portal vein tumour thrombosis (PVTT), hepatic artery, biliary duct or inferior vena cava invasion
- •（2） extrahepatic spread (EHS)
- •（3） albumin-bilirubin grade 1 or 3
- •（4） Eastern Cooperative Oncology Group Performance Status (ECOG-PS) >1
- •（5） tumour number >3
- •（6） other tumours or severe cardiac, cerebral, and renal insufficiency
- •（7）ascites, hepatic encephalopathy, and jaundice
结局指标
主要结局
overall survival
时间窗: 5 year
The overall survival rate at 5 years
次要结局
未报告次要终点
研究者
研究点 (2)
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