Does exercise influence inflammation after a burn injury?

Not Applicable

Completed

• Conditions: Burn induced inflammation; Injuries and Accidents - Burns; Inflammatory and Immune System - Other inflammatory or immune system disorders

• Registration Number: ACTRN12620000237987
• Lead Sponsor: Fiona Stanley Hospital

Brief Summary

he aims of the pilot study were to assess the feasibility of implementing a long duration exercise training program, in burn injured individuals including learnings associated with conducting a clinical trial in COVID-19 pandemic. We found conducting a long duration exercise training study on burn injured individuals is feasible using either supervised training at the hospital or un-supervised training with a home exercise program. There was greater than 95% adherance rate by participants to data collection appointments and to the exercise protocol. The knowledge gained helps improve the methodology in larger-scale projects. Insights into the impact of COVID-19 on this clinical trial and success enhancing adaptations for the researcher, research practice and the participant, are presented

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-02-25
• Study Completion: 2021-06-30
• Last Update Posted: 20 June 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

•greater than or equal to 5%TBSA burn injury
•Time post injury, greater than or equal to 1 year
•Male or female, greater than or equal to18 years old
•Satisfactory self-described health status (excluding burn injury)
•Subject understands the proposed project, is able to consent to participation

Exclusion Criteria

•Acquired or pre-existing neurological injury or disease conditions which influence the capacity to complete future exercise or walking program eg nerve injury or multi-trauma; spinal cord injury, CVA / central nervous system lesions; Patients with no fixed address.
•Intellectually challenged patients
•Non – English speaking
•Pregnant Women
•Cancer
•Unstable cardiac conditions

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
TNF alpha - TNF alpha assay[TNF alpha will be collected at baseline, mid-way (3 weeks) and post intervention (6 weeks) for study periods 1 and 2 (i.e. the exercise and control conditions). ]