Hard and Soft Tissue Dimensional Change After Consecutive Extractions and Unassisted Socket Healing in the Esthetic Zone
- Conditions
- Wound Heal
- Registration Number
- NCT06261762
- Lead Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
- Brief Summary
The goal of this observational study is to evaluate the post-extraction hard and soft tissue dimension changes in patients requiring consecutive extractions and unassisted socket healing in the anterior maxilla. The main questions it aims to answer are:
* Is significant alveolar ridge resorption observed at center sites after consecutive extractions
* Is significant alveolar ridge resorption observed at the interalveolar septum after consecutive extractions, are different extraction sites associated with significantly different bone resorption
* Is a thick or thin wall phenotype associated with the amount of bone resorption
* Is soft tissue thickness change associated with the corresponding location (extraction site or interalveolar septum) and post-extraction thickness of the bone
* Is the interdental papilla height significantly affected after extractions.
Participants will undergo consecutive (two) extractions and will be evaluated after subsequent unassisted socket healing for 8 weeks.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 20
- 18+ years old
- Require consecutive (two) teeth replacement in the anterior maxilla
- Signed informed consent
- No significant medical conditions
- Patients with healthy periodontal conditions or previously treated to controlled and stable conditions
- General medical (American Society of Anesthesiologists, ASA, class III or IV) and/or psychiatric contraindications
- Pregnancy or nursing
- Any interfering medication such as steroid therapy or bisphosphonate therapy
- Uncontrolled diabetes
- Autoimmune diseases or inflammatory diseases affecting the intraoral tissues
- Radiation therapy to head or neck region
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Bone level change from baseline Baseline and at 8 weeks Measured in millimeters using segmented surface model superimpositions. Changes in bone loss between baseline and an 8 week healing period using CBCT. From the Digital Imaging and Communications in Medicine (DICOM) files two surface mesh models were generated, which were superimposed and the changes were subsequently analyzed.
Soft tissue change from baseline Baseline and at 8 weeks Changes in soft tissue loss at baseline and 8 weeks were analyzed using digital dental impressions acquired from intraoral scans, which were superimposed and the changes were analyzed.
- Secondary Outcome Measures
Name Time Method Correlation between baseline facial bone thickness and dimensional soft tissue alterations during healing at the interalveolar septum. Baseline and at 8 weeks To measure correlation, the Spearman Rank Correlation Coefficient was calculated. Nonparametric models for longitudinal data were applied to analyze the impact of bone wall phenotype and healing period upon dimensional alterations.