Effect of Sodium Glucose Co-Transporter 2 Inhibitors on Estimated Glomerular Filtration Rate in Diabetic Versus Non-Diabetic Chronic Kidney Disease Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Change in the estimated glomerular filtration rate
研究概览
简要总结
The work aimed to compare the effects of Sodium-glucose co-transporter-2 (SGLT2) inhibitors on glomerular filtration rate (GFR) in patients with diabetic chronic kidney disease (CKD) and non-diabetic CKD.
详细描述
Glucose reabsorption is mediated by the sodium-glucose cotransporter (SGLT) 2, which reabsorbs 90% of glucose, and SGLT1, which reabsorbs the remaining 10%.
The relationship between hyperglycaemia and the development of renal disease is complex. Hyperglycaemia-induced complications are mediated by several metabolic pathways, among which accumulation of Advanced Glycation End-products with abnormalities of the glycosylation of macromolecules and increased glucose flux through the polyol pathway seem to be the most important.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years.
- •Both sexes.
- •Chronic kidney disease (CKD) participants with stages 3 and 4.
排除标准
- •Patients with type 1 diabetes mellitus (DM).
- •Patients with decompensated Chronic liver disease.
- •Patients with uncontrolled hypertension.
- •Patients with blood pressure (BP) > 110/
- •Patients already on the same medication (Sodium Glucose Co-Transporter 2 Inhibitors).
- •Patients with a history of recurrent or recent urinary tract infection (UTI).
- •Patients with glycated hemoglobin (HbA1c) ≤
- •Adult polycystic kidney disease.
- •All patients on immunosuppressive medications.
结局指标
主要结局
Change in the estimated glomerular filtration rate
时间窗: 6 months post-procedure
Change in the estimated glomerular filtration rate (eGFR) was recorded.
次要结局
未报告次要终点
研究者
Ashraf Hassan
Assistant Professor of Internal Medicine and Nephrology, Faculty of Medicine, Ain shams University, Cairo, Egypt
Ain Shams University