NCT01292161已完成2 期
Study of Silymarin for Improving Hepatitis C
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 55
- 试验地点
- 1
- 主要终点
- Serum aminotransferases (ALT, AST)
研究概览
简要总结
The purpose of this study is to determine the effects of silymarin on outcomes of patients with hepatitis C.
详细描述
Silymarin has been claimed to have a beneficial effect in various types of liver injury, including alcoholic liver disease, drug and toxin induced hepatotoxicity, and acute and chronic viral hepatitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •confirmed chronic hepatitis C (HCV Ab (+), HCV RNA (with PCR) (+)) normal or increased liver enzymes (ALT and AST) not using interferon or ribavirin due to patient sensitivity or not consenting.
排除标准
- •The pregnant patients patients with side effect which confirmed with rechallenge test
研究组 & 干预措施
Silymarin
Other
Silymarin drived from Silybum marianum (milk thistle), a flowering member of the daisy family, may benefit liver function in people infected with the hepatitis C virus.
干预措施: Silymarin (Drug)
结局指标
主要结局
Serum aminotransferases (ALT, AST)
时间窗: at six months after admission
The investigators measured serum amino transferases by commercial AST kit,. ALT kits(Bayer Diagnostics,. Tarrytown, NY, USA) at six months after silymarin admission
次要结局
- HCV-RNA(at six months after admission)
研究者
研究点 (1)
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