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Clinical Trials/NCT05765422
NCT05765422CompletedNot Applicable

Sport and Health a Pilot Study: Impact of Endurance Physical Activity on the Microbiological Homeostasis of the Oral Cavity of Young Adults

Centre Hospitalier Universitaire de Nice2 sites in 1 country103 target enrollmentStarted: October 17, 2022Last updated:
Conditions
Interventions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
103
Locations
2
Primary Endpoint
Analysis of the oral microbiota in healthy individuals engaged in endurance physical activity at different levels.

Study Overview

Brief Summary

The oral cavity is an easily accessible anatomical site that accurately reflects the health of the individual. The mouth is considered an early indicator of biological aging, leading to the identification of oral biomarkers predictive of future alterations. Current data show that the oral health of high level athletes is globally altered with an increase in cariogenic indexes, an increased incidence of periodontitis, dental trauma and dry mouth syndromes. Few studies have focused on the oral microbiota compared to mouthguards used in rugby or boxing which seem to induce dysbiosis, a recent study shows an effect of ketogenic diet on bacterial changes in the mouth of endurance athletes. This project focuses on the impact of intensive sport practice on oral health and the identification of oral biomarkers associated with physical activity. The objective of this study is to investigate the impact of the amount of endurance sport practice on oral microbiota and oral health in young adults. the hypothesis is that a sedentary lifestyle and high-level sport induce depletion and/or changes in the oral microbiota compared to regular physical activity.

Study Design

Study Type
Interventional
Allocation
Non Randomized
Intervention Model
Parallel
Primary Purpose
Basic Science
Masking
None

Eligibility Criteria

Ages
18 Years to 30 Years (Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Be between 18 and 30 years old
  • If practicing sports, it must be an endurance sport as main activity (cycling or running)

Exclusion Criteria

  • Practice more than 3 hours of swimming per week
  • Have taken anti-inflammatory drugs, less than 48 hours before the study
  • Have taken antibiotics and/or probiotics, less than 3 weeks before the study

Arms & Interventions

sedentary

Other

Participant does not meet WHO's recommendations with the physical activity

Intervention: salivar and gum sampling (Other)

OMS recommandations

Other

Participant does not meet WHO's recommendations (2.5-5 hours per week of moderate physical activity OR 1.25-2.5 hours per week of vigorous physical activity);

Intervention: salivar and gum sampling (Other)

More than the OMS recommandations

Other

Participant is practicing physical activity more than the WHO recommendations

Intervention: salivar and gum sampling (Other)

Outcomes

Primary Outcomes

Analysis of the oral microbiota in healthy individuals engaged in endurance physical activity at different levels.

Time Frame: 3 years

Microbiological screening will be performed using an innovative methodology based on microfluidic PCR (BiomarkHD) (number of bacterial colonies)

Secondary Outcomes

  • Quantification of salivary inflammatory markers in healthy individuals who perform endurance physical activity at different levels.(3 years)

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (2)

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