Allopurinol as a possible oxygen sparing agent during exercise in peripheral arterial disease - Allopurinol as a possible oxygen sparing agent during exercise in PAD

niversity of Dundee0 个研究点开始时间: 2010年7月19日最近更新: 2012年9月3日

适应症

试验速览

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•Men and women age 35-85 years suffering from PAD. PAD will be defined as (1) claudication defined as leg pain on walking and disappearing within 10 minutes on standing and of presumed atherosclerotic origin and (2) an ankle brachial pressure index (ABPI) of <0.90 on the worst leg at rest. They will have to demonstrate stable disease by having a reproducible pain free walking distance on 2 consecutive treadmill tests, i.e. less than 25% variance. The reason for termination of the test must be claudication pain only. All treadmill tests will be done at a 12% incline and a speed of 3.2 km/h (= 2 mph), as is standard practice in PAD trials .
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•Exclusion criteria will be rest pain, childbearing potential, heart failure, any other exercise limiting cardiac disease, BP >180/100 mHg, eGFR <60 ml/min, liver disease, malignancy, or already on allopurinol or had an adverse reaction to it. Participants who have had a recent marked change in symptoms or recent (in the last six months) intervention for PAD will also be excluded. Participants receiving treatment with either 6-mercaptopurine, azathioprine, warfarin, or theophylline (prohibited drugs in this study due to a contraindication regarding concomitant treatment) will be excluded from participation.

发起方

niversity of Dundee