Brain TV (Tissue Velocimetry) for Emergency Assessment of Acquired Brain Injury
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Stroke
- Sponsor
- University of Leicester
- Enrollment
- 250
- Locations
- 1
- Primary Endpoint
- MRI measurement
- Last Updated
- 4 years ago
Overview
Brief Summary
This study uses a Doppler ultrasound technique being developed at the University of Leicester called 'Brain Tissue Velocimetry" (Brain TV), to investigate brain tissue motion over the cardiac cycle.
Detailed Description
Brain motion is highly sensitive to heart and brain biomechanics, but the impact of brain injury on brain tissue motion has yet to be explored. Preliminary brain tissue motion measurements from a small number of patients suggest that brain biomechanics may be disturbed in the presence of injury. This study combines Transcranial Tissue Doppler ultrasound with brain MRI to establish whether analysis of brain tissue motion provides clinically useful information for emergency diagnosis and monitoring of acute brain injury.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Participant (or consultee) is willing and able to give informed consent (or assent) for participation in the study.
- •Adult, aged 18 years or over.
- •Suspected Acquired Brain Injury (any severity).
Exclusion Criteria
- •Unable (in the investigators' opinion), or unwilling, to comply with the study requirements.
- •Patients with pre-existing chronic brain conditions that may make affect informed consent, such as severe learning difficulties, dementia, or Alzheimer's disease, will be excluded.
Outcomes
Primary Outcomes
MRI measurement
Time Frame: Up to 5 days.
This study will perform brain MRI for brain tissue motion for selective patients with suspected stroke.
TCTD measurement
Time Frame: Up to 5 days.
The study will generate a library of Brain TV measurements for exploratory (descriptive) analysis and imaging of brain tissue pulsations in patients with suspected stroke to evaluate the potential for clinical device development.