Long-term Assessment of Organ Functions Among Survivors of Severe Acute Respiratory Syndrome

• Conditions: SARS Virus; Long-Term Survivors

• Registration Number: NCT03443102
• Lead Sponsor: Peking University People's Hospital

Brief Summary

SARS-CoV has caused severe epidemic respiratory disease in human populations. By July 2003, a total of 8,096 probable cases of SARS had been reported including 774 deaths in 27 countries, around one-third of which were health care workers (HCWs). Previous studies have been reported about long-term impacts of SARS infection, including lung function deficiency, steroid-induced osteonecrosis, reduced exercise capacity, and impairment in health-related quality of life (HRQoL). HCWs, especially nurses, have been reported to experience greater psychological distress, particularly increased levels of posttraumatic stress symptomatology (PTSS). But the very complex impacts of this fatal infection on HCWs have not been fully elucidated. It is thus important to follow these occupational patients to detect and manage multi-organ sequelae and functional impairment.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-01-25
• Status Verified: 2018-02
• Study First Submitted: 2018-02-04
• Study First Submitted QC: 2018-02-16
• Study First Posted: 2018-02-22
• Last Update Submitted: 2018-02-22
• Last Update Posted: 2018-02-26
• Primary Completion: 2018-07-01
• Study Completion: 2018-12-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• Health care workers who were working at Peking University People's Hospital during the SARS epidemic in 2002-2003

Exclusion Criteria

• Refusal to continue the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
All-cause disability	Evaluations would be finished within 90 days after enrollment.	Disabilities arising from physical injuries and/or mental stresses

Secondary Outcome Measures

Name	Time	Method
Cardiopulmonary function	Evaluations would be finished within 90 days after enrollment.	The interrelationship between the workings of the heart and lung organs would be assessed by assessed by 6MWT (6-min walk test)
Life Life quaities mental distress	Evaluations would be finished within 90 days after enrollment.	Quality of life would be assessed by the Medical Outcomes Study 36-item short form version 2 (SF-36)

Trial Locations

Locations (1)

Peking University People's Hospital; 🇨🇳 Beijing, Beijing, China