Trans-parenchymal Compressing Suture in Major Liver Resection

Not Applicable

Completed

• Conditions: Liver Carcinoma Resectable

• Registration Number: NCT03215290
• Lead Sponsor: Tongji Hospital

Brief Summary

Non-anatomical liver resection with appropriate resection margin was regarded as a potential curative treatment for selected major hepatic carcinoma due to preserving maximal normal liver, especially in cirrhotic patients. But occurrence of cutting surface related complications become a main challenge.

Detailed Description

In order to better manage the cutting surface after liver resection, we further applied trans-parenchymal compressing suture to "not good" cutting surface in hope of decreasing cutting surface related complication. A majority of studies investigating cutting surface management are limited to non-surgical treatments, such as the application of hemostasis agents including fibrin sealants, oxidized cellulose, and absorbable gelatin sponge13-15 . But there is no consensus regarding the necessity of the hemostatic agent application to the liver cutting surface. Up to date, few studies investigate surgical suture management of the cutting surface in liver resection.

Study Timeline

• Study Start: 2016-10
• Primary Completion: 2017-01
• Study Completion: 2017-02
• Study First Submitted: 2017-06-29
• Status Verified: 2017-07
• Study First Submitted QC: 2017-07-10
• Last Update Submitted: 2017-07-10
• Study First Posted: 2017-07-12
• Last Update Posted: 2017-07-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 382

Inclusion Criteria

1. tumor size more than 5cm
2. non-anatomical liver resection;

Exclusion Criteria

1. intravascular infiltration with tumor embolus;
2. previous liver surgical treatment (e.g. microwave ablation; preoperative transcatheter arterial chemoembolization (TACE);
3. other concomitant extrahepatic procedures (e.g. splenectomy).
4. exposed Glisson Shealth, main hepatic veins or (and) retro-hepatic inferior vena cava.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Cutting surface related complications	90 days	After liver resection, some complication related cutting surface may occur, including surgery site infection, bile leakage, bleeding.

Secondary Outcome Measures

Name	Time	Method
Interventions for cutting surface related complications	90 days	Once the cutting surface related complications occur, some interventions need to be performed to treat these complications, such as percutaneous abdominal paracentesis or reoperation.