Evaluation of Electrical Velocimetry for Assessment of Extra-vascular Lung Water in Pre-eclamptic Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- total thoracic fluid content
研究概览
简要总结
The purpose of this study is to compare the sensitivity and the specificity of electrical cardiometry to the lung ultrasound in measuring thoracic lung water in pregnant females with pre-eclampsia. If electrical cardiometry is validated against ultrasound, it will be easy to use with numerical number that will not require advanced experience as with the ultrasound.
详细描述
Pre-eclampsia is accompanied with increased risk of serious complications such as pulmonary edema, cerebrovascular accidents, coagulopathy, and hemorrhage.
Pre-eclampsia is responsible for 46.6% of the etiology of acute pulmonary edema in pregnant women.
Fluid management in pre-eclamptic patients is challenging. Hypovolemia exacerbates organ failure, whereas volume overload results in pulmonary edema. Thus, using different methods for evaluation of volume status of the patients would improve patient management. Lung ultrasound has been developed as an accurate non-invasive method for assessment of extra-vascular lung water; However, ultrasound needs skilled operator. Electrical velocimetry (cardiometry) is a newer technology for assessment of total thoracic fluid content (TFC); however, it has not been validated in pre-eclamptic patients.
In this study the investigators will validate the accuracy of cardiometry in evaluation of lung water using the lung ultrasound as a gold standard. Both methods will be evaluated for prediction of the need of diuretic therapy and the need for post-operative oxygen therapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •pre-eclamptic
- •In first stage of labor
排除标准
- •Eclampsia.
- •Second, third and fourth stages of labor on admission.
- •Patients with severe cardiac and/or pulmonary disease.
结局指标
主要结局
total thoracic fluid content
时间窗: after 30 minutes from patient admission to the obstetric casuality
total fluid content measured by electrical velocimetry device (cardiometry)
次要结局
- The need of diuretics(during the period starting from admission till one day after delivery)
- extra-vascular lung water(after 30 minutes from patient admission to the obstetric casuality)
- lung congestion(during the period starting from admission till one day after delivery)
- heart rate(after 30 minutes from patient admission to the obstetric casuality)
- arterial blood pressure(after 30 minutes from patient admission to the obstetric casuality)
- serum albumin(after 30 minutes from patient admission to the obstetric casuality)
研究者
Ahmed Hasanin
Lecturer of anesthesia and critical care medicine
Cairo University