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Clinical Trials/NCT05551260
NCT05551260CompletedNot Applicable

Assessing Moral Cognitive Skills in Adults With Autism Spectrum Disorders

Hôpital le Vinatier2 sites in 1 country60 target enrollmentStarted: May 2, 2023Last updated:
Conditions
Interventions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
60
Locations
2
Primary Endpoint
Evaluation of moral cognition

Study Overview

Brief Summary

In the international literature, it is currently accepted that, relative to neurotypicals, people with Autism Spectrum Disorder (ASD) present patterns of moral judgments marked by a minimization of intentionality and a strong condemnation of agents responsible for accidents. However, until now, all studies are based on declarative paradigms, and no one has proposed to examine the relationship of people with ASD to moral transgressions (i.e. to a bad action done deliberately or to a good deed deliberately omitted) in an implicit paradigm, that is, when the answer is made on the assignment of an expressive face to these moral offenses. Furthermore, no study has investigated whether diminished sensitivity to intention and intransigence of incidental judgment occur in both automatic (implicit) and deliberative (explicit) settings.

Investigators planned to study how people with ASD without intellectual disability process emotions expressed by others in response to different forms of moral offense and to examine whether patterns potentially contrast in degree and/or kind with those of neurotypicals.

Detailed Description

In the CoMorA project, participants will participate to two independent tasks: an explicit one of deciding whether or not an emotion expressed on the face of a third person would be an appropriate emotional reaction to the offense, and an implicit one in which the subjects will have to determine the fastest sex to which the face expressing such or such an emotion belongs. This procedure initiates an implicit processing of the facial expression.

The theoretical hypotheses of the CoMorA project are the following:

  • In the explicit response condition, people with ASD will show different emotional assignment patterns than controls do, depending on the nature of the offense (accidental transgression, attempted harm, and intentional harm).
  • In the implicit response condition, people with ASD will exhibit emotion processing patterns identical to those of controls.
  • The differences in responses of controls and people with ASD in the explicit condition will be underpinned by executive functions and social cognitive performances.

Study Design

Study Type
Interventional
Allocation
Non Randomized
Intervention Model
Parallel
Primary Purpose
Prevention
Masking
None

Eligibility Criteria

Ages
18 Years to 40 Years (Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Diagnosis of ASD according to DSM-5 criteria
  • Age between 18 and 40 years old
  • Francophone
  • Affiliated to social security
  • Having given their consent to participate in the study
  • Patient under guardianship and curatorship
  • Neurotypical group:
  • Age between 18 and 40 years old
  • Francophone
  • Affiliated to a social security scheme
  • Having given their consent to participate in the study

Exclusion Criteria

  • Diagnosis of intellectual development disorder established according to DSM-5 criteria
  • Language, sensory or motor impairments hindering participation in the study
  • Control group:
  • Neurodevelopmental pathology (declarative)
  • Neurological pathology
  • Language, sensory or motor impairments hindering participation in the study

Arms & Interventions

People with ASD

Experimental

30 people with ASD without IDD

Intervention: Neuropsychological assessments (tests allowing to measures attentional, executive and emotional performances) and experimental protocol assessing moral cognition (Other)

Neurotypicals

Active Comparator

30 neurotypicals

Intervention: Neuropsychological assessments (tests allowing to measures attentional, executive and emotional performances) and experimental protocol assessing moral cognition (Other)

Outcomes

Primary Outcomes

Evaluation of moral cognition

Time Frame: between day 1 and day 21

First the reading of a vignette presenting a moral scenario jointly manipulating variables of intention and consequence. This systematic manipulation, commonly used in the field of moral judgment, leads to 4 combinations of variables: intentional harm: present intention; present consequence attempted harm: present intention; absent consequence accidental harm: absent intention; present consequence accidental harm with positive intention: positive intention; present consequence A presentation to the participants of a face presenting an intense facial expression (in a counterbalanced way of man or woman 1\. Implicit procedure: The participants will participate to an implicit task consisting in classifying as quickly as possible the sex to which the character of the photograph belongs (male or female). The response time (TR) will be recorded.

Secondary Outcomes

  • Social cognitive measures(at day 0 and between day 1 and day 21)
  • Reasoning and general intellectual level(at day 0 and between day 1 and day 21)
  • Attentional and executive measures(at day 0 and between day 1 and day 21)
  • Alexithymia(at day 0 and between day 1 and day 21)

Investigators

Sponsor
Hôpital le Vinatier
Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (2)

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