PERFUSION INDEX AS A PREDICTOR FOR HYPOTENSION IN ELDERLY PATIENTS UNDERGOING HERNIOPLASTY UNDER SPINAL ANAESTHESIA-AN OBSERVATIONAL STUDY
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- CORRELATION BETWEEN BASELINE PERFUSION INDEX AND THE CHANGES IN MEAN ARTERIAL PRESSURE IN THE INTRAOPERATIVE PERIOD
研究概览
简要总结
Spinal anaesthesia is one of the commonly used anaesthetic technique in elderly patients. It tends to be safe and simple procedure and also avoid the various complications associated with general anaesthesia. Despite many recent advances, haemodynamic instabilities associated with it is a daily challenge for the anaesthesiologists. Post spinal anaesthesia hypotension occurs due to sympatholysis, leading to loss of tone of venous capacitance vessels and drop in central venous pressure . Hypotension caused by the spinal anaesthesia is proportional to the spinal anaesthesia block height .Elderly age group having a compromised cardiopulmonary system and reduced physiological reserve makes these hemodynamic instabilities more intolerable as they cannot effectively increase the cardiac output .Intra operative hypotension management by infusion of fluids and crystalloids is effective but can lead to fluid overload in this group of patients. Moreover, vasopressors used to combat hypotension can cause tachycardia, hypertension and coronary ischaemia .
The perfusion index (PI) is relatively a new parameter estimating the plusatility of blood in the extremities, calculated using infrared spectrum. It can be easily derived from a pulse oximeter noninvasively. It assesses peripheral perfusion dynamics occurring due to changes in peripheral vascular tone. PI is calculated as the ratio of pulsatile blood flow to non-pulsatile blood in peripheral tissue. The formula for its calculation is as follows
Perfusion index = AC÷DC × 100
Where AC is the infrared signal’s pulsating component and is the light absorbed by the pulsatile blood flow in the artery. The normal range of PI is 0.02% (very feeble strength) to 20% (very strong strength ). PI estimates the status of microcirculation which is densely innervated by sympathetic nerves. Therefore, multiple factors altering the systemic vascular resistance (SVR) can be assessed by this indicator. The resting SVR can influence incidence and severity of post-spinal hypotension. Value of PI can be used to assess (SVR). Therefore, assuming that vasodilatation reflecting higher baseline PI can been associated with reduction in blood pressure (BP) following spinal anaesthesia. Previous studies regarding the baseline PI and hypotension following spinal anaesthesia have shown positive correlation in parturients undergoing caesarean surgery.. Not much study has done assessing the correlation between the incidence of post spinal hypotension and PI in elderly age group. Therefore, the aim of this study is to find the correlation between baseline perfusion index and incidence of hypotension in elderly patients undergoing hernioplasty under spinal anaesthesia.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 45.00 Year(s) 至 70.00 Year(s)(—)
- 性别
- All
入选标准
- •ASA PHYSICAL STATUS I AND II UNDERGOING ELECTIVE HERNIOPLASTY UNDER SPINAL ANAESTHESIA.
排除标准
- •PATIENTS HAVING CONTRAINDICATIONS FOR SPINAL ANAESTHESIA,LIKE LACK OF CONSENT, RAISED INTRACRANIAL TENSION,INFECTION AT LOCAL SITE, SEVERE AORTIC STENOSIS, COAGULOPATHY,CARDIOVASCULAR INSTABILITY 2) PATIENTS WITH KNOWN ALLERGY TO THE DRUGS INJECTION HEAVY BUPIVACAINR AND FENTANYL 3)PATIENTS RECEIVING ANTIHYPERTENSIVE MEDICATIONS OR VASODILATOR AGENTS 4) PATIENTS WITH BMI >30kg/m2 5)PATIENTS HAVING HEIGHT <150 cm 6)PATIENTS ASA PHYSICAL STATUS III OR MORE 7) PATIENTS HAVING MAJOR CARDIOVASCULAR,RESPIRATORY,RENAL,HEPATIC ,NEUROLOGICAL OR ENDOCRINE DISEASES 8)PATIENTS REQUIRING GENERAL ANAESTHESIA.
结局指标
主要结局
CORRELATION BETWEEN BASELINE PERFUSION INDEX AND THE CHANGES IN MEAN ARTERIAL PRESSURE IN THE INTRAOPERATIVE PERIOD
时间窗: 12 months
次要结局
- 1) CORRELATION BETWEEN BASELINE PERFUSION INDEX AND THE CHANGES IN SYSTOLIC BLOOD PRESSURE AND DIASTOLIC BLOOD PRESSURE INTRAOPERATIVELY(2) CORRELATION BETWEEN BASELINE PERFUSION INDEX AND TIME OF REQUIREMENT OF FIRST DOSE OF PHENYLEPHRINE,TOTAL PHENYL EPHRINE REQUIREMENT , TOTAL INTRAVENOUS FLUID REQUIREMENT AND INCIDENCE OF NAUSEA AND VOMITING)
研究者
SREELAKSHMI PV
CALCUTTA NATIONAL MEDICAL COLLEGE AND HOSPITAL
