跳至主要内容
临床试验/CTRI/2024/01/061751
CTRI/2024/01/061751尚未招募不适用

PERFUSION INDEX AS A PREDICTOR FOR HYPOTENSION IN ELDERLY PATIENTS UNDERGOING HERNIOPLASTY UNDER SPINAL ANAESTHESIA-AN OBSERVATIONAL STUDY

CALCUTTA NATIONAL MEDICAL COLLEGE AND HOSPITAL1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2024年1月29日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
40
试验地点
1
主要终点
CORRELATION BETWEEN BASELINE PERFUSION INDEX AND THE CHANGES IN MEAN ARTERIAL PRESSURE IN THE INTRAOPERATIVE PERIOD

研究概览

简要总结

Spinal anaesthesia is one of the commonly used anaesthetic technique in elderly patients. It tends to be safe and simple procedure and also avoid the various complications associated with general anaesthesia. Despite many recent advances, haemodynamic instabilities associated with it is a daily challenge for the anaesthesiologists. Post spinal anaesthesia hypotension occurs due to sympatholysis, leading to loss of tone of venous capacitance vessels and drop in central venous pressure . Hypotension caused by the spinal anaesthesia is proportional to the spinal anaesthesia block height .Elderly age group having a compromised cardiopulmonary system and reduced physiological reserve makes these hemodynamic instabilities more intolerable as they cannot effectively increase the cardiac output .Intra operative hypotension management by infusion of fluids and crystalloids is effective but can lead to fluid overload in this group of patients. Moreover, vasopressors used to combat hypotension can cause tachycardia, hypertension and coronary ischaemia .

The perfusion index (PI) is relatively a new parameter estimating the plusatility of blood in the extremities, calculated using infrared spectrum. It can be easily derived from a pulse oximeter noninvasively. It assesses peripheral perfusion dynamics occurring due to changes in peripheral vascular tone. PI is calculated as the ratio of pulsatile blood flow to non-pulsatile blood in peripheral tissue. The formula for its calculation is as follows

Perfusion index   = AC÷DC × 100

Where AC is the infrared signal’s pulsating component and is the light absorbed by the pulsatile blood flow in the artery. The normal range of PI is 0.02% (very feeble strength) to 20% (very strong strength ). PI estimates the status of microcirculation which is densely innervated by sympathetic nerves.  Therefore, multiple factors altering the systemic vascular resistance (SVR) can be assessed by this indicator.  The resting SVR can influence incidence and severity of post-spinal hypotension. Value of PI can be used to assess (SVR). Therefore, assuming that vasodilatation reflecting higher baseline PI can been associated with reduction in blood pressure (BP) following spinal anaesthesia. Previous studies regarding the baseline PI and hypotension following spinal anaesthesia have shown positive correlation in parturients undergoing caesarean surgery.. Not much study has done assessing the correlation between the incidence of post spinal hypotension and PI in elderly age group. Therefore, the aim of this study is to find the correlation between baseline perfusion index and incidence of hypotension in elderly patients undergoing hernioplasty under spinal anaesthesia.

研究设计

研究类型
Observational

入排标准

年龄范围
45.00 Year(s) 至 70.00 Year(s)(—)
性别
All

入选标准

  • ASA PHYSICAL STATUS I AND II UNDERGOING ELECTIVE HERNIOPLASTY UNDER SPINAL ANAESTHESIA.

排除标准

  • PATIENTS HAVING CONTRAINDICATIONS FOR SPINAL ANAESTHESIA,LIKE LACK OF CONSENT, RAISED INTRACRANIAL TENSION,INFECTION AT LOCAL SITE, SEVERE AORTIC STENOSIS, COAGULOPATHY,CARDIOVASCULAR INSTABILITY 2) PATIENTS WITH KNOWN ALLERGY TO THE DRUGS INJECTION HEAVY BUPIVACAINR AND FENTANYL 3)PATIENTS RECEIVING ANTIHYPERTENSIVE MEDICATIONS OR VASODILATOR AGENTS 4) PATIENTS WITH BMI >30kg/m2 5)PATIENTS HAVING HEIGHT <150 cm 6)PATIENTS ASA PHYSICAL STATUS III OR MORE 7) PATIENTS HAVING MAJOR CARDIOVASCULAR,RESPIRATORY,RENAL,HEPATIC ,NEUROLOGICAL OR ENDOCRINE DISEASES 8)PATIENTS REQUIRING GENERAL ANAESTHESIA.

结局指标

主要结局

CORRELATION BETWEEN BASELINE PERFUSION INDEX AND THE CHANGES IN MEAN ARTERIAL PRESSURE IN THE INTRAOPERATIVE PERIOD

时间窗: 12 months

次要结局

  • 1) CORRELATION BETWEEN BASELINE PERFUSION INDEX AND THE CHANGES IN SYSTOLIC BLOOD PRESSURE AND DIASTOLIC BLOOD PRESSURE INTRAOPERATIVELY(2) CORRELATION BETWEEN BASELINE PERFUSION INDEX AND TIME OF REQUIREMENT OF FIRST DOSE OF PHENYLEPHRINE,TOTAL PHENYL EPHRINE REQUIREMENT , TOTAL INTRAVENOUS FLUID REQUIREMENT AND INCIDENCE OF NAUSEA AND VOMITING)

研究者

发起方
CALCUTTA NATIONAL MEDICAL COLLEGE AND HOSPITAL
申办方类型
Government medical college
责任方
Principal Investigator
主要研究者

SREELAKSHMI PV

CALCUTTA NATIONAL MEDICAL COLLEGE AND HOSPITAL

研究点 (1)

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