The Influencing Factors of Vancomycin Trough Level and the Rate Achieving the Target Trough Level in Critically Ill Patients: A Retrospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 165
- 主要终点
- Rate of patients achieving the target vancomycin trough（15-20mg/L）
研究概览
简要总结
The aim of this study was to assess factors that may influence vancomycin trough level and the rate achieving the target trough level in critically ill patients.
详细描述
This retrospective observational study included adult patients treated with intravenous vancomycin in intensive care unit of Zhongda Hospital from January 2015 to December 2017. Vancomycin dose was based on international consensus and adjusted according to estimated glomerular filtration rate (eGFR) calculated by the Cockcroft-Gault equation. vancomycin trough level (VTL) was retained at steady state (after the third dose). Linear regression was performed to determine the correlation between factors prior to the first vancomycin dose and VTL. Distribution of VTL and percentage of patients achieving the target trough level (15-20mg/L) was observed in different renal function.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult ICU patients (age≥18 years) treated with intravenous vancomycin were included
排除标准
- •Chronic renal dysfunction and acute renal injury patients treated with Renal Replacement therapy
- •VTL was not retained at steady-state
- •Vancomycin treatment time≤48h
- •Vancomycin dose did not meet study definitions
- •Palliative care
结局指标
主要结局
Rate of patients achieving the target vancomycin trough（15-20mg/L）
时间窗: 3 years
Vancomycin trough level was retained at steady state (after the third dose). If a patient has multiple measurements of vancomycin trough level, the first measurement is collected.Rate of patients achieving the target trough level (15-20mg/L) was observed.
次要结局
未报告次要终点
研究者
Jingyuan,Xu
Principal Investigator
Southeast University, China