Effect of pioglitazone and metformin in combination with insulin therapy in patients with type 2 diabetes
Not Applicable
- Conditions
- Type 2 diabetes
- Registration Number
- JPRN-UMIN000003830
- Lead Sponsor
- Chigasaki Municipal Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 250
Inclusion Criteria
Not provided
Exclusion Criteria
1) Patients with type 1 diabetes 2) Patients receiving thiazolidiones or biguanides 3) Heart failure defined as NYHA class III or above 4) Having allergy to thiazolidiones or biguanides 5) Patients with severe liver failure or renal failure 6) History of acute coronary syndrome or cerebrovascular accident with in 3 months 7) Pregnant or breastfeeding 8) Patients with familial hypercholesterolemia 9) Other patients determined to be inappropriate by physician
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes of HbA1c from the baseline to 24 weeks later
- Secondary Outcome Measures
Name Time Method body weight change, fasting plasma glucose, postprandial plasma glucose, insulin dose requirements, lipid profile(Total cholesterol,Triglyceride,LDL-cholesterol,HDL-cholesterol), albuminuria, Cystatin C, High sensitivity CRP