Prevalence of Nasal Hyperreactivity in Chronic Upper Airway Inflammation: a Prevalence Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 756
- 试验地点
- 1
- 主要终点
- Comparison of the proportion of patients and healthy volunteers with nasal hyperreactivity
研究概览
简要总结
Rhinitis, or inflammation of the nasal mucosa, can present with nasal obstruction, nasal discharge, itch or sneezing. If the sinusal mucosa is involved as well, it is called rhinosinusitis and facial pain or loss of smell is possible. Several causes are known, such as an underlying allergy ("allergic rhinitis", AR). If at least 2 symptoms are present for at least 12 weeks, it is called "chronic rhinosinusitis" (CRS).
Up to 2/3 of the AR and CRS patients have symptoms upon exposure to triggers such as sudden temperature changes, smoke, fragrances... a phenomenon called "nasal hyperreactivity" (NHR). It is currently not clear why some patients suffer NHR while others do not.
In this study, the investigators want to determine the prevalence and severity of nasal hyperreactivity in patients with chronic upper airway inflammation. To this end, patients and healthy controls will be asked to fill out a questionnaire inquiring presence and severity of nasal symptoms upon exposure to particular environmental triggers.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age 18-65 y
- •Nasal inflammatory symptoms for 12 weeks or longer (nasal obstruction, post-nasal drip, rhinorrhea, loss of smell, sneezing/itch, facial pain)
- •Signed informed consent
排除标准
- •Current or medical history of malignancy in the last ten years
- •Inclusion Criteria:
- •age 18-65 y
- •No nasal inflammatory symptoms for 12 weeks or longer (nasal obstruction, post-nasal drip, rhinorrhea, loss of smell, sneezing/itch, facial pain)
- •Signed informed consent
- •Exclusion Criteria:
- •Current or medical history of malignancy in the last ten years
结局指标
主要结局
Comparison of the proportion of patients and healthy volunteers with nasal hyperreactivity
时间窗: 3 months
Every participant will fill out a questionnaire inquiring presence of nasal symptoms evoked by environmental triggers and lasting longer than ten minutes (nasal hyperreactivity). The proportion of patients and healthy volunteers with nasal hyperreactivity will be compared.
次要结局
- Comparison of the proportion of healthy volunteers and four groups of patients (allergic rhinitis, non-allergic non-infectious rhinitis, chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis without nasal polyps) with nasal hyperreactivity.(3 months)
- Comparison of nasal symptom severity in healthy volunteers and four groups of patients [allergic rhinitis, non-allergic non-infectious rhinitis, chronic rhinosinusitis (CRS) with and CRS without nasal polyps] with and without nasal hyperreactivity.(3 months)
- Comparison of nasal symptom severity in patients and healthy volunteers with and without nasal hyperreactivity.(3 months)
研究者
Laura Van Gerven
Professor doctor
Universitaire Ziekenhuizen KU Leuven