The Mechanism Research of Angiotensin II Pathway and Postoperative Hypoxemia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 88
- 试验地点
- 1
- 主要终点
- The Difference Concentrations of ANG II in Serum Between Patients With and Without Postoperative Hypoxemia.
研究概览
简要总结
Acute type A aortic dissection is often accompanied by postoperative hypoxemia, the cause of which is not fully understood. Angiotensin II is an important component of the renin-angiotensin system (RAS), which has been suggested to be involved in the development of aortic dissection and pulmonary inflammation.The purpose of this study was to investigate the role and mechanism of angiotensin II pathway in postoperative hypoxemia after acute type A aortic dissection, and to provide reference for clinical application
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing surgery for acute type A aortic dissection
- •age between 18 to 80
排除标准
- •perioperative severe cardiac insufficiency
- •rejection of consent
结局指标
主要结局
The Difference Concentrations of ANG II in Serum Between Patients With and Without Postoperative Hypoxemia.
时间窗: Within 24 hours after surgery
Blood samples were taken within 24 hours after operation to detect the contents of ANG II in serum. Postoperative hypoxemia is defined by the oxygenation index (OI), which is the ratio of arterial partial pressure of oxygen to fraction inspired oxygen (PaO2 / FiO2), of less than or equal to 200 for two consecutive times within the first 24 h after operation
次要结局
- Duration of Stay in the Intensive Care Unit(up to 60 days)
- The Risk Factors for Postoperative Hypoxemia in Stanford Type A Acute Aortic Dissection Patients.(up to 60 days)
研究者
Jun Ma
The chief of department of anesthesiology
Beijing Anzhen Hospital