Organosilane for Surface Cleaning in Intensive Care Units

Phase 2

Recruiting

• Conditions: Infection, Hospital
• Interventions: Other: Surface disinfection with Organosilane

• Registration Number: NCT05673226
• Lead Sponsor: Hospital Israelita Albert Einstein

Brief Summary

The purpose of this study is to evaluate if surface disinfection with organosilane associated with traditional cleaning reduces the incidence of healthcare-associated infections (HAIs) in intensive care units when compared with traditional cleaning alone.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-12-07
• Study First Submitted QC: 2023-01-05
• Study First Posted: 2023-01-06
• Status Verified: 2023-11
• Study Start: 2023-11-06
• Last Update Submitted: 2024-01-05
• Last Update Posted: 2024-01-09
• Primary Completion: 2024-11-04
• Study Completion: 2024-12-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 13000

Inclusion Criteria

• All patients aged 18 years and older who will be admitted to the participating ICUs

Exclusion Criteria

• Patients under 18 years
• ICUs that may use any organosilane formulation for surface disinfection

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Surface disinfection with organosilane	Surface disinfection with Organosilane	Organosilane will be sprayed on the surfaces, using an atomizer. When the environment has been completely covered (i.e., when all surfaces and equipment have a slightly damp film), we will proceed with the second phase of the disinfection of all heavily touched surfaces. surfaces of the bed, with a microfiber cloth with organosilane.

Primary Outcome Measures

Name	Time	Method
Incidence of healthcare associated infections	6 months

Secondary Outcome Measures

Name	Time	Method
Incidence of ventilator-associated pneumonia	6 months
Intensive care unit length of stay costs	6 months
Incidence of catheter-associated urinary tract infection	6 months
Contamination of environmental surfaces by multi-resistant microorganisms	6 months	We will collect environmental samples from 4 surfaces highly touched by the patient, health team and family (bed rails, monitor and infusion pump buttons, meal table or procedure table, and IV drip stand) before and after the intervention. (end of the 6 months). For analysis of the environmental samples, characterization of the density and microbiological profile of biofilms on the different surfaces of the ICU beds will be performed using large-scale DNA sequencing techniques associated with bioinformatics analysis.
Incidence of central line-associated blood stream infections	6 months

Trial Locations

Locations (14)

Hospital Presidente Vargas; 🇧🇷 São Luís, Brazil

A.C. Camargo Cancer Center; 🇧🇷 São Paulo, Brazil

Santa Casa de Misericórdia; 🇧🇷 Belo Horizonte, Brazil

Hospital Jean Bittar; 🇧🇷 Belém, Brazil

Hospital de Base do Distrito Federal; 🇧🇷 Brasília, Brazil

Hospital Otoclínica; 🇧🇷 Fortaleza, Brazil

Hospital Geral de Goiânia; 🇧🇷 Goiânia, Brazil

Hospital Ana Nery; 🇧🇷 Salvador, Brazil

Hospital Ernesto Dornelles; 🇧🇷 Porto Alegre, Brazil

Hospital Santa Cruz; 🇧🇷 Santa Cruz Do Sul, Brazil

Hospital Universitário de Brasília; 🇧🇷 Brasília, Brazil

Hospital do Tricentenário; 🇧🇷 Olinda, Brazil

Hospital Escola Universidade Federal de Pelotas; 🇧🇷 Pelotas, Brazil

Hospital do Coração; 🇧🇷 São Paulo, Brazil