Pupillometry for Pain Assessment in Critically Ill Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Correlation coefficient of pupillary light reflex amplitude and pain score
研究概览
简要总结
This study was part of a quality improvement project at the Department of Anesthesiology and Intensive Care Medicine, Charité - Universitaetsmedizin Berlin.
Being in pain is reported to be one of the most important stressors in critically ill patients and worsens outcome. The evaluation of pain using validated scores in patients who are able to self-report significantly improves the quality of analgesic therapy and health related outcomes in intensive care patients.
However, behavioral pain score that are used in sedated or delirious patients, often underestimate the severity of pain.
The primary aim of this study is to investigate if measurement of the pupillary light reflex Amplitude correlates with the results of pain assessment using validated pain scores in critically ill patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •critically ill patients
- •aged 18 years or older
- •patients with an expected intensive care unit length of stay of of at least 48 hours.
排除标准
- •not German speaking
- •traumatic brain injury
- •increased intracranial pressure
- •ocular disease or surgery.
结局指标
主要结局
Correlation coefficient of pupillary light reflex amplitude and pain score
时间窗: Participants will be followed up to 6 days during their intensive care unit stay
Pain is measured by Numeric Rating Scale - Visualised or Behavioural Pain Scale or Behavioral Pain Scale - Non Intubated and pupillary light reflex amplitude is measured by pupillometry
次要结局
- Latency of pupil [ms](Participants will be followed up to 6 days during their intensive care unit stay)
- Minimal pupil size [mm](Participants will be followed up to 6 days during their intensive care unit stay)
- Maximal pupil size [mm](Participants will be followed up to 6 days during their intensive care unit stay)
- Pupillary light reflex [%](Participants will be followed up to 6 days during their intensive care unit stay)
- Morbidity Scores(Participants will be followed up during their intensive care unit stay, an average of 25 days)
- Glasgow Coma Scale (GCS)(Participants will be followed up to 6 days during their intensive care unit stay)
- Delirium(Participants will be followed up to 6 days during their intensive care unit stay)
- Contraction speed of pupil [mm/s](Participants will be followed up to 6 days during their intensive care unit stay)
- Duration of mechanical ventilation (hours)(Participants will be followed up during their intensive care unit stay, an average of 25 days)
- Amount of administered drugs(Participants will be followed up to 6 days during their intensive care unit stay)
- Richmond Agitation Sedation Scale (RASS)(Participants will be followed up to 6 days during their intensive care unit stay)
- Intensive care unit length of stay (days)(Participants will be followed up during their intensive care unit stay, an average of 25 days)
- Hospital length of stay (days)(Participants will be followed up during their hospital length of stay, an average of 5 weeks)
- Hospital mortality (days)(Participants will be followed up during their hospital length of stay, an average of 5 weeks)
- Discharge to home [%](Participants will be followed up during their hospital length of stay, an average of 5 weeks)
研究者
Claudia Spies
Head of Department of Anesthesiology and Intensive Care Medicine CVK/CCM
Charite University, Berlin, Germany