Assessment of Hypoxia Before Radioembolization Treatment With 18F-FMISO PET
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- Demonstrate the effect of the hypoxia in the success of the radioembolization treatment
研究概览
简要总结
Hypoxia is a known factor for resistance to radiotherapy in tumors. Response to transarterial radioembolization is known to be variable between different patients even if the same dose of radiation was delivered. In this study the investigators aim to quantify the hypoxia in the primary and secondary tumors of liver with 18F-FMISO PET before radioembolization and to prove any effect of the hypoxia, if present, on the dose that should be delivered to tumor to ensure treatment response.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with colorectal carcinoma with liver metastasis or hepatocellular carcinoma.
- •Is not eligible for surgery
- •Above 18 years old
- •The patients who are referred for transarterial radioembolization treatment to Ankara University School of Medicine Department of Nuclear Medicine.
排除标准
- •Patients with ECOG performance score >1
- •Claustrophobia
- •Life expectancy shorter than 3 months
- •Pregnant or breast-feeding patients
结局指标
主要结局
Demonstrate the effect of the hypoxia in the success of the radioembolization treatment
时间窗: 08/2024
Demonstrate the effect of the hypoxia in the success of the radioembolization treatment
The effect of the hypoxia on the dose-response relationships and required doses to achieve treatment response in the hypoxic and non-hypoxic group.
时间窗: 08/2024
The effect of the hypoxia on the dose-response relationships and required doses to achieve treatment response in the hypoxic and non-hypoxic group.
次要结局
未报告次要终点